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TranscriptomicsRegulating RNA Polymerase Pausing and Elongation in Embryonic Stem Cell Transcription
Transitions between pluripotent stem cells and differentiated cells are executed by key transcription regulators. Comparative measurements of RNA polymerase distribution over the genomeM-bM-^@M-^Ys primary transcription units in different cell states can identify the genes and steps in the transcrip...
ORGANISM(S): Mus musculus 
2011-04-01 | E-GEOD-27037 | biostudies-arrayexpress
TranscriptomicsA methyl-deviator epigenotype of estrogen-receptor-positive breast carcinoma is associated with malignant biology
We broadly profiled DNA methylation in breast cancers (n=351) and benign parenchyma (n=47) for correspondence with disease phenotype using formalin-fixed paraffin-embedded (FFPE) diagnostic surgical pathology specimens. Exploratory analysis revealed a distinctive primary invasive carcinoma subclass ...
ORGANISM(S): Homo sapiens 
2011-12-08 | E-GEOD-29428 | biostudies-arrayexpress
TranscriptomicsOncogenic SDH mutation underlies global epigenomic instability in gastrointestinal stromal tumor
We have discovered a striking connection between mitochondrial dysfunction and epigenomic instability, manifested by global biallelic DNA cytosine 5-methylation and loss of 5-hydroxymethycytosine within succinate dehydrogenase (SDH)-null gastrointestinal stromal tumors (GIST) relative to those beari...
ORGANISM(S): Homo sapiens 
2013-05-22 | E-GEOD-34387 | biostudies-arrayexpress
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