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ProteomicsTranscriptomic and Proteomic Signatures of Stemness and Differentiation in the Colon Crypt
The intestinal epithelium is replaced weekly by non-quiescent stem cells with kinetics that rely on a rapid loss of stemness and choice for secretory or absorptive lineage differentiation. To determine how the cellular transcriptome and proteome changes during these transitions, we developed a new c...
ORGANISM(S): Mus Musculus (mouse) 
2020-07-15 | PXD019351 | JPOST Repository
GenomicsDNA binding activities of the C-clamp
Investigated the DNA binding specificity of the C-clamp of dnTCF1E Used a doxycycline inducible system to investigate the role of the C-clamp in the genome-wide binding of dnTCF1E. Induced dnTCF1EWT and dnTCF1Emut (C-clamp mutant that is null for C-clamp DNA binding) over 2 time points (2 hours and...
ORGANISM(S): Homo sapiens 
2014-12-04 | E-GEOD-53536 | biostudies-arrayexpress
TranscriptomicsExpression data from three human DLD-1-derived colon cancer cell lines
The LEF/TCF family of transcription factors are downstream effectors of the WNT signaling pathway, which drives colon tumorigenesis. LEF/TCFs have a DNA sequence-specific HMG box that binds Wnt Response Elements (WREs). The “E tail” isoforms of TCFs are alternatively spliced to include a second DN...
ORGANISM(S): Homo sapiens 
2012-05-31 | E-GEOD-37964 | biostudies-arrayexpress
ProteomicsFacile one-pot nanoproteomics for label-free proteome profiling of 50-1000 mammalian cells
We report a facile one-pot nanoproteomics method termed SOPs-MS (Surfactant-assisted One-Pot sample processing at the standard volume coupled with MS) for convenient proteome profiling of 50-1000 mammalian cells. Building upon our recent development of SOP-MS for label-free single-cell proteomics at...
ORGANISM(S): Homo Sapiens (human) Mus Musculus (mouse) 
2022-05-11 | PXD025918 | JPOST Repository
ProteomicsFacile one-pot nanoproteomics for label-free proteome profiling of 50-1000 mammalian cells
We report a facile one-pot nanoproteomics method termed SOPs-MS (Surfactant-assisted One-Pot sample processing at the standard volume coupled with MS) for convenient proteome profiling of 50-1000 mammalian cells. Building upon our recent development of SOP-MS for label-free single-cell proteomics at...
ORGANISM(S): Homo Sapiens (human) Mus Musculus (mouse) 
2021-07-23 | PXD026009 | JPOST Repository
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