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TranscriptomicsGenome-wide analysis of germ cell proliferation in C. elegans
Proliferating germ cells in C. elegans provide a useful model system for deciphering fundamental mechanisms underlying the balance between proliferation and differentiation. Using gene expression profiling of mutants with excess germ cell proliferation, we identified approximately 200 genes express...
ORGANISM(S): Caenorhabditis elegans 
2010-04-29 | E-GEOD-21531 | biostudies-arrayexpress
ProteomicsChicken spermatozoa protein extract analyzed by Top-down HRMS
Currently, evaluation of quality semen is based on traditional in vitro sperm tests as measures of motility, viability and acrosomic reaction. However, the results are not always well correlated with real male fertility. In the present study, we evaluated Intact Cell MALDI-TOF Mass Spectrometry (ICM...
ORGANISM(S): Gallus gallus (Chicken) 
2016-04-11 | PXD002768 | Pride
Chicken Top-down Spermatozoa 
ProteomicsFollicular cells Top-down proteomic
In mammals, the capacity of the female germ cell, the oocyte, to develop into embryo is acquired throughout meiotic maturation. Immature oocyte cannot be fertilized while mature oocyte is apt to accept spermatozoa and to develop an embryo. In a follicle, the oocyte is surrounded by mural granulosa c...
ORGANISM(S): Bos taurus (Bovine) 
2017-04-10 | PXD004892 | Pride
Oocytes Μlc-ms/ms Cumulus cells Top-down proteomic Granulosa cells 
ProteomicsThe proteomic landscape and temporal dynamics of mammalian gastruloid development
Gastrulation is the highly coordinated process by which the early embryo breaks symmetry, establishes germ layers and a body plan, and sets the stage for organogenesis. As early mammalian development is challenging to study in vivo, stem cell-derived models have emerged as powerful surrogates, e.g. ...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2026-03-02 | PXD054460 | Pride
ProteomicsTargeting of SUMOylation leads to cBAF complex stabilization and disruption of the SS18::SSX transcriptome in Synovial Sarcoma
Synovial Sarcoma (SS) is driven by the SS18::SSX fusion oncoprotein and is ultimately refractory to therapeutic approaches. SS18::SSX alters ATP-dependent chromatin remodeling BAF (mammalian SWI/SNF) complexes, leading to the degradation of canonical (cBAF) complex and amplified presence of an SS18:...
ORGANISM(S): Homo sapiens (Human) 
2025-08-07 | PXD059936 | Pride
Synovial sarcoma  baf complexes  swi/snf  sumoylation  tak-981  subasumstat  dna damage  targeted therapy 
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