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TranscriptomicsExamination of the role of BMP signaling in patterning of human pluripotent stem cell derived mid/hindgut spheroids and maintenance of this patterning in organoids transplanted under mouse kidney capsules.
The goal of this study was to test the hypothesis that BMP signaling regulates patterning of human CDX2+ gut tube cultures (Spence et al 2011, Watson et al. 2014). The study is comprised of 2 separate experiments. The first experiment was to determine the immediate impact of BMP signaling on CDX2+ g...
ORGANISM(S): Homo sapiens 
2017-04-20 | E-MTAB-5658 | biostudies-arrayexpress
TranscriptomicsExpanding the MicroRNA Targeting Code: A Novel Type of Site with Centered Pairing
We present “centered sites,” a class of microRNA target sites that lacks both perfect seed pairing and 3'-compensatory pairing and instead has 11–12 contiguous Watson–Crick pairs to the center of the microRNA. In elevated Mg2+, centered sites impart mRNA cleavage, but in cells, centered sites repre...
ORGANISM(S): Homo sapiens 
2010-06-25 | E-GEOD-22068 | biostudies-arrayexpress
TranscriptomicsExpression data from the PVD and OLL neurons in C. elegans
Nociceptive neurons develop a complex dendritic arbor to sense noxious stimuli, which enables animals to react to environmental insults and perform self-protective behaviours. The genetic programs controlling neuronal dendritic morphogenesis are poorly understood. In C. elegans, the PVD sensory neur...
ORGANISM(S): Caenorhabditis elegans 
2010-07-08 | E-GEOD-21162 | biostudies-arrayexpress
UnknownClinical and biomarker modifiers of vitamin D treatment response: the Multi-Ethnic Study of Atherosclerosis.
Not available
S-EPMC8895207 | biostudies-literature
MetabolomicsMetabolomic Profiling of Submaximal Exercise at a Standardised Relative Intensity in Healthy Adults
Ten physically active subjects underwent two cycling exercise trials. In the first, aerobic capacity (VO2max) was determined and the second was a 45 min submaximal exercise test. Urine samples were collected separately the day before (day 1), the day of (day 2), and the day after (day 3) the submaxi...
2017-05-16 | MTBLS306 | MetaboLights
UnknownFactors associated with D-dimer levels in HIV-infected individuals.
Not available
S-EPMC3953205 | biostudies-literature
Unknown16. A Randomized Phase 1 Study of a Novel Pneumococcal Conjugate Vaccine in Healthy Japanese Adults in the United States
Not available
S-EPMC7776113 | biostudies-literature
TranscriptomicsWhole genome expression array profiling highlights differences in mucosal defense genes in Barrett's esophagus and esophageal adenocarcinoma.
Esophageal adenocarcinoma (EAC) has become a major concern in Western countries due to rapid rises in incidence coupled with very poor survival rates. One of the key risk factors for the development of this cancer is the presence of Barrett’s esophagus (BE), which is believed to form in response to ...
ORGANISM(S): Homo sapiens 
2011-08-16 | E-GEOD-28302 | biostudies-arrayexpress
UnknownThe Multi-Ethnic Study of Atherosclerosis individual response to vitamin D trial: Building a randomized clinical trial into an observational cohort study.
Not available
S-EPMC8089051 | biostudies-literature
TranscriptomicsLincRNAs involved in DCS-induced fear extinction: Shedding light on the transcriptomic dark matter
There is a growing appreciation of the role of non-coding RNAs in the regulation of gene and protein expression. Long non-coding RNAs can modulate splicing by hybridizing with precursor messenger RNAs (pre-mRNAs) and influence RNA editing, mRNA stability, translation activation and microRNA-mRNA int...
ORGANISM(S): Rattus norvegicus 
2020-03-01 | E-MTAB-8647 | biostudies-arrayexpress
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