Sort   by:  
 Page size 
TranscriptomicsDermal reprogramming through epidermal activation of beta-catenin
Hair follicle formation depends on reciprocal epidermal-dermal interactions and occurs during skin development, but not in adult life. This suggests that the properties of dermal fibroblasts change during postnatal development. To examine this, we used a PdgfraEGFP mouse line to isolate GFP-positive...
ORGANISM(S): Mus musculus 
2011-10-12 | E-GEOD-32966 | biostudies-arrayexpress
GenomicsGenome-wide maps of Gata6 in primary mouse keratinocytes
In adult K14Î?NLef1 mouse, the overexpression of â??NLef1, a Ã?-catenin dominat negative, in basal keratinocytes leads to the conversion of hair follicles into multilayered epithelial cysts and ectopic sebaceous gland. â??NLef1 transcriptional activity led to Gata6 overexpression in the pilosebaceou...
ORGANISM(S): Mus musculus 
2017-05-16 | E-GEOD-62607 | biostudies-arrayexpress
TranscriptomicsGene expression signature of Gata6 positive epidermal cells.
To characterize gene expression in Gata6 positive epidermal cells we analyzed a Gata6 reporter mouse in which the endogenous Gata6 promoter drives expression of mTomato. We performed flow cytometry followed by transcriptome analysis. We compared four subpopulations of telogen epidermal cells: Gata6+...
ORGANISM(S): Mus musculus 
2017-05-16 | E-GEOD-62606 | biostudies-arrayexpress
TranscriptomicsGene expression signature of the three major epidermal differentiation compartments: interfollicular epidermis (IFE), hair follicle (HF) and sebaceous gland (SG).
There are multiple stem cells in adult mammalian epidermis, but the mechanisms controlling lineage specification are poorly understood. To identify gene expression signatures of the three major epidermal differentiation compartments we micro-dissected individual SG, IFE and HF from adult epidermis. ...
ORGANISM(S): Mus musculus 
2017-05-16 | E-GEOD-62604 | biostudies-arrayexpress
TranscriptomicsEpidermal overexpression of ∆NLef1 leads to deregulation of epidermal stem cell fate.
In adult K14ΔNLef1 mouse, the overexpression of ∆NLef1, a B-catenin dominat negative, in basal keratinocytes leads to the conversion of hair follicles into multilayered epithelial cysts and ectopic sebaceous gland. To uncover in vivo changes in gene expression associated to ∆NLef1 activity, we ...
ORGANISM(S): Mus musculus 
2017-05-16 | E-GEOD-62603 | biostudies-arrayexpress
ProteomicsHipSci project proteomics batch 1, comprising 6 IPS cell lines from 3 donors
The Human Induced Pluripotent Stem Cells Initiative (HipSci) is generating a large, high-quality reference panel of human IPSC lines. This is a submission of mass-spectrometry analyses from 6 induced pluripotent stem cell lines generated by the HipSci project.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-05-15 | MSV000081088 | MassIVE
ProteomicsHipSci project pilot submission for 18 IPS cell lines
The Human Induced Pluripotent Stem Cells Initiative (HipSci) is generating a large, high-quality reference panel of human IPSC lines. This is a pilot submission of mass-spectrometry analyses from 18 induced pluripotent stem cell lines generated by the HipSci project. This submission includes also da...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-07-24 | MSV000080004 | MassIVE
Sort   by:  
 Page size