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Transcription factors that play key roles in regulating embryonic stem (ES) cell state have been identified, but the chromatin regulators that help maintain ES cells are less well understood. A high-throughput shRNA screen was used to identify novel chromatin regulators that influence ES cell state...
ORGANISM(S): Mus musculus 
This was a randomised study in terminally anaesthetised female cross-bred Large White pigs. Initially, animals were anaesthetised and instrumented for continuous physiological monitoring and sampling; blood samples were collected upon initiation of the surgery (line-in, T = -150 minutes). Following ...
ORGANISM(S): Sus scrofa 
Glioblastoma-derived neural stem (GNS) cells were reprogrammed to induced pluripotent stem (iPS) cells by transgenic expression of OCT4 and KLF4. Genome-wide DNA methylation status was profiled at 27,578 CpG sites to assess epigenetic erasure and restoration due to reprogramming and redifferentiatio...
ORGANISM(S): Homo sapiens 
Glioblastoma-derived neural stem (GNS) cells were reprogrammed to induced pluripotent stem (iPS) cells by transgenic expression of OCT4 and KLF4. Genome-wide DNA methylation status was profiled at 485,000 loci to assess epigenetic erasure and restoration due to reprogramming and redifferentiation to...
ORGANISM(S): Homo sapiens 
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