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TranscriptomicsAffymetrix data for training of Endopredict algorithm
These data, combined with other cohorts (GSE6532, GSE12093, and qRT-PCR based cohorts), was used to construct the EP algorithm, which predicts the likelihood of developing of a distant recurrence of early stage breast cancer under endocrine treatment. In addition, EPclin, a combination of the EP sco...
ORGANISM(S): Homo sapiens 
2011-10-10 | E-GEOD-26971 | biostudies-arrayexpress
TranscriptomicsFIR inhibition in HCC cells (Hep3B)
siRNA-mediated inhibition compared to untreated cells and cells transfected with nonsense siRNA Together with far upstream element binding protein (FBP), the FBP-interacting repressor (FIR) represents a molecular tool for the transcriptional fine tune regulation of target genes. Previous evidence in...
ORGANISM(S): Homo sapiens 
2014-09-03 | E-GEOD-55692 | biostudies-arrayexpress
TranscriptomicsWhole-genome oxidative bisulfite sequencing and data processing of mouse intestinal stem cells with old and young mitochondria
The intent of the study was to profile the methylome and hydroxymethylome in intestinal stem cells with young mitochondria or old old mitochdondria, to ascertain the potential role of mitochondrial age specific influence on epigenetic regulation of ISCs.
ORGANISM(S): Mus musculus 
2025-05-07 | E-MTAB-15119 | biostudies-arrayexpress
TranscriptomicsDifferential gene expression in WT mice and mice lacking PTPN2 in T cells
WT mice and mice lacking PTPN2 in T cells (PTPN2-CD4Cre mice) were treated with AOM/DSS to induce colorectal tumours. RNA was isolated from tumour and non-tumour tissues in the colon. Colon samples from water-treated WT and PTPN2-CD4Cre mice served as additional control. Total RNA was isolated and t...
ORGANISM(S): Mus musculus 
2020-10-03 | E-MTAB-9629 | biostudies-arrayexpress
TranscriptomicsRNA-seq of Dm-aKG treated intestinal stem cells (ISCs) and controls
The object of this study was to investigate how aKG impacts mouse intestinal stem cell (ISCs) function and fate decisions in vivo. Mice were treated for 7 days with twice daily aKG IP injections after which ISCs were FACS sorted and transcriptomically anayzled. This revealed a striking set of secret...
ORGANISM(S): Mus musculus 
2025-05-02 | E-MTAB-15105 | biostudies-arrayexpress
TranscriptomicsRNA-seq of mice TRAF2/Casp-8LPC-KO tumors
This model was used to study the relationship between NF-kB and PCD regulation and generated mice with combined conditional ablation of Traf2 and Caspase-8 (TRAF2/Casp-8LPC-KO) in order to block apoptosis and specifically study the role of necroptosis in Traf2-deficient hepatocytes in vivo.
ORGANISM(S): Mus musculus 
2019-05-31 | E-MTAB-4598 | biostudies-arrayexpress
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