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ProteomicsBenefit of circadian clocks in adaptive immunity and vaccination responses
The adaptive immune response is under circadian control, yet, the benefit of this rhythmicity for the organism is unknown. Furthermore, it is not understood why adaptive immune reactions continue to exhibit circadian changes over long periods of time. Using a combination of experimental and mathemat...
ORGANISM(S): Mus musculus (Mouse) 
2023-02-08 | PXD039050 | Pride
Mathematical modeling Adaptive immunity Sars-cov-2 Bmal1 Hepatitis a Circadian rhythm Vaccination Leukocyte trafficking 
UnknownOverall Survival in Patients With Advanced Melanoma Who Received Nivolumab Versus Investigator's Choice Chemotherapy in CheckMate 037: A Randomized, Controlled, Open-Label Phase III Trial.
Not available
S-EPMC6804912 | biostudies-literature
TranscriptomicsCAR-adapted PIK3CD base editing enhances T cell anti-tumor potency
Insufficient functional T cell persistence impedes therapeutic success of chimeric antigen receptor (“CAR”) therapies. Here, we performed a CAR-adapted base editing screen of PIK3CD, a key regulator of T cell function, metabolism, and fate. We identified point mutations that beneficially modulate CA...
ORGANISM(S): Homo sapiens 
2025-11-06 | E-MTAB-15749 | biostudies-arrayexpress
TranscriptomicsRNA-seq of mice TRAF2/Casp-8LPC-KO tumors
This model was used to study the relationship between NF-kB and PCD regulation and generated mice with combined conditional ablation of Traf2 and Caspase-8 (TRAF2/Casp-8LPC-KO) in order to block apoptosis and specifically study the role of necroptosis in Traf2-deficient hepatocytes in vivo.
ORGANISM(S): Mus musculus 
2019-05-31 | E-MTAB-4598 | biostudies-arrayexpress
UnknownA genome-wide association meta-analysis of prognostic outcomes following cognitive behavioural therapy in individuals with anxiety and depressive disorders.
Not available
S-EPMC6533285 | biostudies-literature
UnknownBehavioural and functional evidence revealing the role of RBFOX1 variation in multiple psychiatric disorders and traits.
Not available
S-EPMC9734045 | biostudies-literature
UnknownIntra-operative defibrillation testing and clinical shock efficacy in patients with implantable cardioverter-defibrillators: the NORDIC ICD randomized clinical trial.
Not available
S-EPMC4589656 | biostudies-literature
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