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ProteomicsThe leader peptide peTrpL forms antibiotic-containing ribonucleoprotein complexes for posttranscriptional regulation of multiresistance genes
Bacterial ribosome-dependent attenuators are widespread posttranscriptional regulators. They harbour small upstream ORFs (uORFs) encoding leader peptides, for which no functions in trans are known yet. In the soil-dwelling plant symbiont Sinorhizobium meliloti, the tryptophan biosynthesis gene trpE(...
ORGANISM(S): Rhizobium meliloti (Ensifer meliloti) (Sinorhizobium meliloti) 
2020-05-19 | PXD018342 | Pride
Small proteins Posttranscriptional regulation Attenuator Multiresistance Sinorhizobium meliloti Quantification 
TranscriptomicsRNA-seq of the ventral compartment of the middle gluteal muscle in untrained at resting Thoroughbred horses, comparing the age of two years old and three years old
The development stage between two and three years old of age is very important for Thoroughbred horses, as the Thoroughbred horses would experience high intense exercise and training. This study was designed to investigate the transcriptional changes in the skeletal muscle of untrained Thoroughbred ...
ORGANISM(S): Equus caballus 
2026-05-20 | E-MTAB-15170 | biostudies-arrayexpress
UnknownAn Optimized Lentiviral Vector Efficiently Corrects the Human Sickle Cell Disease Phenotype.
Not available
S-EPMC6105766 | biostudies-literature
ProteomicsPD-1-targeted immunotherapy in NASH-triggered liver cancer induces pro-tumorigenic environment through CD8+PD-1+ T-cells
Immunotherapy has opened hitherto unknown possibilities to treat cancer. Whereas some cancer types (e.g. melanoma) can be efficiently treated, others lack measurable positive effects (e.g. PDAC). Moreover, stratification of responders/non-responders is only possible in some cancer types (e.g. melano...
ORGANISM(S): Mus musculus (Mouse) 
2021-03-03 | PXD017236 | Pride
Immunotherapy Cd8+pd1+ Nash 
UnknownThe Thyroid Hormone Transporter Mct8 Restricts Cathepsin-Mediated Thyroglobulin Processing in Male Mice through Thyroid Auto-Regulatory Mechanisms That Encompass Autophagy.
Not available
S-EPMC7796480 | biostudies-literature
UnknownStructure-Guided Engineering of a Versatile Urethanase Improves Its Polyurethane Depolymerization Activity.
Not available
S-EPMC11967865 | biostudies-literature
UnknownEditing a γ-globin repressor binding site restores fetal hemoglobin synthesis and corrects the sickle cell disease phenotype.
Not available
S-EPMC7015694 | biostudies-literature
UnknownPrevention of psychosocial distress consequences in somatic hospital inpatients via a stepped and collaborative care model: protocol of SomPsyNet, a stepped wedge cluster randomised trial.
Not available
S-EPMC10668178 | biostudies-literature
UnknownPlerixafor enables safe, rapid, efficient mobilization of hematopoietic stem cells in sickle cell disease patients after exchange transfusion.
Not available
S-EPMC5927997 | biostudies-literature
ProteomicsImpact of de novo variants in the PSMC5 coding the AAA-ATPase proteasome subunit PSMC5/Rpt6 on the protein pattern of patient-derived primary T-cells in comparison to their wild-type counterparts.
To better understand the cellular consequences of mutations in the AAA-ATPase proteasome subunit PSMC5/Rpt6, we performed a mass spectrometry-based comparative analysis of the T-cell proteome of subjects with PSMC5 mutations to that of their wild-type counterparts.
ORGANISM(S): Homo sapiens (Human) 
2025-08-07 | PXD048558 | Pride
Protein homeostasis Psmc5 variants Proteasome Primary t-cells 
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