Sort   by:  
 Page size 
TranscriptomicsLeishmania major infection-induced changes in the small RNA transcriptome of host macrophages.
Protozoan parasites of the genus Leishmania are the causative agent of leishmaniasis, one of the 13 most important tropical diseases. Leishmania persists as endo-parasite in host macrophages, where it uses multiple strategies to manipulate the microbicidal host cell functions and to escape from the ...
ORGANISM(S): Mus musculus 
2015-08-03 | E-GEOD-58369 | biostudies-arrayexpress
TranscriptomicsLeishmania major modulates autophagy in host macrophages during intracellular differentiation
Autophagy generally participates in innate immunity by elimination of intracellular pathogens. However, many of them developed successful strategies to counteract their autolysosomal digestion and lastly to exploit this catabolic cellular process. Protozoan parasites of the genus Leishmania are the ...
ORGANISM(S): Mus musculus 
2015-08-03 | E-GEOD-52624 | biostudies-arrayexpress
TranscriptomicsKDM6 Inhibition induces DNA Damage Response (DDR) during ESC Differentiation but not during self-renewal.
The discovery of the first histone demethylase in 2004 (LSD1/KDM1) opened new avenues for the understanding of how histone methylation impacts cellular functions. A great number of histone demethylases have been identified since, which are potentially linked to gene regulation as well as to stem cel...
ORGANISM(S): Mus musculus 
2016-03-11 | E-GEOD-49886 | biostudies-arrayexpress
TranscriptomicsEffect of methylphenidate on gene expression profiles of Attention Deficit Hyperactivity Disorder patients and unaffected controls.
Attention deficit hyperactivity disorder (ADHD) is a common psychiatric condition of children with a prevalence of 5-10% worldwide. Up to 30% of adults with a history of childhood ADHD maintain symptoms in later life; these adult ADHD patients are severely impaired in social and professional life d...
ORGANISM(S): Homo sapiens 
2014-09-05 | E-GEOD-52889 | biostudies-arrayexpress
TranscriptomicsExpression data from human CD4 or CD8 T-cells isolated from PBMC cultured at a low cell density (LDC) or high cell density (HDC)
Research in human immunobiology is mainly based on working with peripheral blood mononuclear cells (PBMC). However, recent investigations have shown that circulating CD4+ T cells are less sensitive to several T-cell activating monoclonal antibodies (mAb) and to recall antigens as compared to tissue-...
ORGANISM(S): Homo sapiens 
2015-06-09 | E-GEOD-51288 | biostudies-arrayexpress
TranscriptomicsThe activation of IL-1-induced enhancers depends on TAK1 kinase activity and NF-kappaB p65 I
The inflammatory gene response requires activation of the protein kinase TAK1, but it is currently unknown how TAK1-derived signals coordinate transcriptional programs in the genome. We determined the genome-wide binding of the TAK1-controlled NF-M-NM-:B subunit p65 in relation to active enhancers a...
ORGANISM(S): Homo sapiens 
2014-12-17 | E-GEOD-64201 | biostudies-arrayexpress
Sort   by:  
 Page size