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TranscriptomicsLudwig Institute/UCSD ENCODE project June 2007 Release
The readout of genome information is controlled by transcriptional regulatory elements, but a comprehensive view of the combinatorial control by these DNA sequences, which bind regulatory protein and/or the modified histones in regulating gene transcription, is clearly preliminary. We have developed...
ORGANISM(S): Homo sapiens 
2007-06-01 | E-GEOD-7872 | biostudies-arrayexpress
TranscriptomicsLudwig Institute/UCSD ENCODE project August 2007 Release
The readout of genome information is controlled by transcriptional regulatory elements, but a comprehensive view of the combinatorial control by these DNA sequences, which bind regulatory protein and/or the modified histones in regulating gene transcription, is clearly preliminary. We have developed...
ORGANISM(S): Homo sapiens 
2010-05-15 | E-GEOD-8887 | biostudies-arrayexpress
TranscriptomicsRegulation of epidermal growth factor receptor signaling in human cancer cells by microRNA-7
The epidermal growth factor receptor (EGFR) is frequently overexpressed in cancer and is an important therapeutic target. Aberrant expression and function of microRNAs has been associated with tumorigenesis. Bioinformatic predictions suggest that the human EGFR mRNA 3’-untranslated region contains t...
ORGANISM(S): Homo sapiens 
2009-01-23 | E-GEOD-14507 | biostudies-arrayexpress
TranscriptomicsWnt5A promotes an adaptive, senescent-like stress response, while continuing to drive invasion in melanoma cells.
We have previously shown that Wnt5A drives invasion in melanoma. We have also shown that Wnt5A promotes resistance to therapy designed to target the BRAF(V600E) mutation in melanoma. Here, we show that melanomas characterized by high levels of Wnt5A respond to therapeutic stress by increasing p21 an...
ORGANISM(S): Homo sapiens 
2015-08-07 | E-GEOD-50004 | biostudies-arrayexpress
GenomicsGene fusion discovery through RNA sequencing of nine human glioblastoma stem cell lines

We used massively parallel, paired-end sequencing of expressed transcripts (RNA-seq) to detect novel gene fusions in short-term cultures of glioma stem-like cells freshly isolated from nine patients carrying primary glioblastoma multiforme (GBM). The culture of primary GBM tumors under serum-free...

phs000505.v1.p1 | EGA
TranscriptomicsTranscription profiling by array of human glioblastoma frozen tumors and cell lines
We have developed a nonheuristic genome topography scan (GTS) algorithm to characterize the patterns of genomic alterations in human glioblastoma (GBM), identifying frequent p18INK4C and p16INK4A codeletion. Functional reconstitution of p18INK4C in GBM cells null for both p16INK4A and p18INK4C resul...
ORGANISM(S): Homo sapiens 
2008-06-16 | E-GEOD-9171 | biostudies-arrayexpress
TranscriptomicsHuman GBM tumor vs Normal Human DNA
We have developed a nonheuristic genome topography scan (GTS) algorithm to characterize the patterns of genomic alterations in human glioblastoma (GBM), identifying frequent p18INK4C and p16INK4A codeletion. Functional reconstitution of p18INK4C in GBM cells null for both p16INK4A and p18INK4C resul...
ORGANISM(S): Homo sapiens 
2008-04-29 | E-GEOD-9177 | biostudies-arrayexpress
TranscriptomicsFeedback Circuit among INK4 Tumor Suppressors Constrains Human Glioblastoma Development
We have developed a nonheuristic genome topography scan (GTS) algorithm to characterize the patterns of genomic alterations in human glioblastoma (GBM), identifying frequent p18INK4C and p16INK4A codeletion. Functional reconstitution of p18INK4C in GBM cells null for both p16INK4A and p18INK4C resul...
ORGANISM(S): Homo sapiens 
2008-04-29 | E-GEOD-9200 | biostudies-arrayexpress
UnknownDexamethasone in Hospitalized Patients with Covid-19.
Not available
S-EPMC7383595 | biostudies-literature
UnknownEffects of empagliflozin on quality of life and healthcare use and costs in chronic kidney disease: a health economic analysis of the EMPA-KIDNEY trial.
Not available
S-EPMC12274867 | biostudies-literature
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