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TranscriptomicsCombined epigallocatechin-3-gallate and resveratrol supplementation for 12 wk increases mitochondrial capacity and fat oxidation, but not insulin sensitivity, in obese humans: a randomized controlled trial
The obese, insulin resistant state is characterized by impairments in lipid metabolism. Dietary polyphenols might improve these deteriorations. We have previously shown that 3-days supplementation of combined Epigallocatechin-gallate and Resveratrol (E+R) increased energy expenditure, which was acco...
ORGANISM(S): Homo sapiens 
2016-08-03 | E-GEOD-71614 | biostudies-arrayexpress
TranscriptomicsLimb immobilization induces a coordinate down-regulation of mitochondrial and other metabolic pathways in men and women
Advancements in animal models and cell culture techniques have been invaluable in the elucidation of molecular events and mechanisms regulating muscle atrophy. However, few studies have examined muscle atrophy in humans using modern experimental techniques. The purpose of this study was to examine a...
ORGANISM(S): Homo sapiens 
2009-02-21 | E-GEOD-14901 | biostudies-arrayexpress
GenomicsSelection for improved energy efficiency and drought tolerance in canola results in distinct transcriptome and epigenome changes [ChIP-Seq]
Integrated breeding strategies are used to increase both the yield potential and stability of crops. Most of these approaches have a direct genetic basis. The utility of epigenetics in breeding to improve complex traits such as yield and stress tolerance is not clear. A better understanding of th...
ORGANISM(S): Brassica napus 
2015-06-28 | E-GEOD-65571 | biostudies-arrayexpress
TranscriptomicsTranscriptomic assessment of resistance to effects of an aryl hydrocarbon receptor (AHR) agonist in embryos of Atlantic killifish (Fundulus heteroclitus) from a marine Superfund site
This study presents statistical analyses of gene expression in 5, 10 and 15 day post-fertilization (dpf) embryos of the teleost Fundulus heteroclitus treated with control vehicle (DMSO) or a potent non-ortho-PCB (PCB-126; 3,3’,4,4’,5-pentachlorobiphenyl). The embryos were from two populations: a cl...
ORGANISM(S): Fundulus heteroclitus 
2011-06-06 | E-GEOD-25245 | biostudies-arrayexpress
TranscriptomicsMusashi 2 is a regulator of the hematopoietic stem cell compartment identified by a retroviral insertion screen and knockout mice
We have used a retroviral integration screen to search for novel genes that regulate hematopoietic stem cell (HSC) function. One of the genes that conferred HSC dominance when overexpressed due to an adjacent retroviral insertion was Musashi 2 (Msi2), an RNA binding protein that can act as a transla...
ORGANISM(S): Mus musculus 
2011-05-21 | E-GEOD-29432 | biostudies-arrayexpress
GenomicsOsmotic stress induces phosphorylation of histone H3 at threonine 3 in pericentromeric regions of Arabidopsis thaliana [ChIP-Seq]
Histone phosphorylation plays key roles in stress-induced transcriptional reprogramming in metazoans but its function(s) in land plants has remained relatively unexplored. Here we report that an Arabidopsis mutant defective in At3g03940 and At5g18190, encoding closely related Ser/Thr protein kinases...
ORGANISM(S): Arabidopsis thaliana 
2015-07-22 | E-GEOD-68370 | biostudies-arrayexpress
GenomicsConserved epigenomic signatures between mouse and human elucidate immune basis of Alzheimer's disease
Alzheimer’s disease (AD) is a severe1 age-related neurodegenerative disorder characterized by accumulation of beta-amyloid (Aβ) plaques and neurofibrillary tangles, synaptic and neuronal loss, and cognitive decline. Several genes have been implicated in AD, but chromatin state alterations during ne...
ORGANISM(S): Mus musculus 
2015-02-18 | E-GEOD-65159 | biostudies-arrayexpress
TranscriptomicsRNA-seq of the brain of Nothobranchius furzeri at different time points
Background: Comparison of temporal gene expression profiles (www.jenage.de) The RNA-seq data comprises 5 age groups: 5,12,20,27,39 weeks 25 samples: 5 biological replicates for each age group
ORGANISM(S): Nothobranchius furzeri 
2014-07-29 | E-GEOD-52462 | biostudies-arrayexpress
TranscriptomicsJnk1 in murine hepatic stellate cells is a crucial mediator of liver fibrogenesis
Hepatic fibrosis is a wound-healing response to chronic liver injury, which may result in cirrhosis and liver failure. The c-Jun N-terminal kinase-1 (JNK1) gene has been shown to be involved in liver fibrosis. Here, we aimed to investigate the molecular mechanism and identify the cell-type involved ...
ORGANISM(S): Mus musculus 
2013-11-27 | E-GEOD-40041 | biostudies-arrayexpress
TranscriptomicsAdiponectin improves local lipid metabolism in regenerating pancreatic islets after β-cell ablation
Pathways that stimulate β-cell regeneration remain of great clinical interest, yet effective therapeutic avenues that promote survival or reconstitution of β-cell mass remain elusive. Utilizing a mouse model with inducible β-cell apoptosis followed by adiponectin-mediated regeneration, we aimed to i...
ORGANISM(S): Mus musculus 
2015-01-09 | E-GEOD-64787 | biostudies-arrayexpress
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