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TranscriptomicsTranscriptome analysis of murine thymocytes reveals age-associated changes in thymic gene expression
The decline in adaptive immunity, naïve T-cell output and a contraction in the peripheral T cell receptor (TCR) repertoire with age are largely attributable to thymic involution and the loss of critical cytokines and hormones within the thymic microenvironment. To assess the molecular changes associ...
ORGANISM(S): Mus musculus 
2009-05-05 | E-GEOD-15945 | biostudies-arrayexpress
ProteomicsStromal Changes in The Aged Lung Induce an Emergence From Melanoma Dormancy
Disseminated cancer cells (DCCs) that escape the primary site can seed in distal tissues, but may take several years, or even decades to grow out into overt metastases, a phenomenon termed tumor dormancy. Despite its importance in metastasis and residual disease, few studies have been able to succes...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2022-03-03 | MSV000088977 | MassIVE
TranscriptomicsNRG1/ERBB3 signaling in melanocyte Melan-Ink4a cells
Neuregulin (NRG) signaling through the receptor tyrosine kinase, ERBB3, is required for embryonic development, and dysregulated signaling has been associated with cancer progression. Here, we show that NRG1/ERBB3 signaling inhibits melanocyte (MC) maturation and promotes undifferentiated, migratory ...
ORGANISM(S): Mus musculus 
2010-05-07 | E-GEOD-21463 | biostudies-arrayexpress
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