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ProteomicsQuantitative phosphoproteomics of chronic sunitinib treated renal cell carcinoma 786-O cells with GPR30 agonist G-1
In this project, we generated chronic sunitinib-treated 786-O cell, a renal cell carcinoma cell line. In order to investigate the possible effect of GPR30 agonist, G-1, on the growth-inhibtion related signaling pathways, we treated either parental both parental and chronic sunitinib-treated 786-O ce...
ORGANISM(S): Homo sapiens (Human) 
2021-04-28 | PXD021254 | Pride
Renal cell carcinoma Sunitinib Gpr30 
ProteomicsDiptoindonesin G is a middle domain HSP90 modulator for cancer treatment
HSP90 inhibitors can target many oncoproteins simultaneously, but none have made it through clinical trials due to dose-limiting toxicity and induction of heat shock response, leading to clinical resistance. We identified diptoindonesin G (dip G) as an HSP90 modulator that can promote degradation of...
ORGANISM(S): Homo sapiens (Human) 
2022-11-16 | PXD035398 | Pride
Esr1  hsp90  heat shock  lbd mutations  diptoindonesin g  hsp90 inhibitor  y537s  hsp90 middle domain  er alpha 
UnknownSYNE1-QK1 SNPs, G × G and G × E interactions on the risk of hyperlipidaemia.
Not available
S-EPMC7214174 | biostudies-literature
UnknownHepatitis G virus infection in patients with chronic non-A-E hepatitis.
Not available
S-EPMC4842868 | biostudies-literature
GenomicsChIP-Sequencing of AL5 over-expressing Arabidopsis and its knock out mutant
Plant homeodomain (PHD) finger proteins affect growth and development by regulating transcription and reading epigenetic modifications of histones, but their functions in abiotic stress responses remain largely unclear. Here we characterize seven Arabidopsis thaliana Alfin1-like PHD finger proteins ...
ORGANISM(S): Arabidopsis thaliana 
2014-04-12 | E-GEOD-56706 | biostudies-arrayexpress
UnknownAssociations of PRKN-PACRG SNPs and G × G and G × E interactions with the risk of hyperlipidaemia.
Not available
S-EPMC7400760 | biostudies-literature
GenomicsGlobal Mapping of Histone H3 K4 and K27 Trimethylation: Lineage Fate Determination of Differentiating CD4+ T Cells
Multipotential naïve CD4+ T cells differentiate into distinct lineages including Th1, Th2, Th17, and inducible T regulatory (iTreg) cells. The remarkable diversity of CD4+ T cells begs the question whether the observed changes reflect terminal differentiation with heritable epigenetic modifications ...
ORGANISM(S): Mus musculus 
2009-01-21 | E-GEOD-14254 | biostudies-arrayexpress
MetabolomicsMechanism of interventional effect and targets of Zhuyu Pill in regulating and suppressing colitis and cholestasis

Zhuyu pill (ZYP) is a traditional Chinese medicine prescription composed of two drugs, Coptis chinensis Franch. and Tetradium ruticarpum (A. Jussieu) T. G. Hartley, and is commonly used in the clinical treatment of diseases of the digestive system. However, the mechanism underly...

2022-11-02 | MTBLS4980 | MetaboLights
UnknownReview of Anhoplocampa Wei (Hymenoptera, Tenthredinidae), with description of a new species and a new combination.
Not available
S-EPMC3253638 | biostudies-literature
ModelsLemon2003_Ca2Dynamics
This a model from the article: Metabotropic receptor activation, desensitization and sequestration-I: modelling calcium and inositol 1,4,5-trisphosphate dynamics following receptor activation. Lemon G, Gibson WG, Bennett MR. J Theor Biol 2003 Jul 7;223...
2005-01-01 | MODEL1006230039 | BioModels
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