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TranscriptomicsGPR30-mediated estrogen signaling in Estrogen Receptor alpha and beta negative SKBR3 breast cancer cells
Gene expression analyses were carried out to identify genes regulated by 17-beta estradiol (E2) and Hydroxytamoxifen (OHT) through GPR30 in SKBR3 cells, a breast cancer cell-line which expresses GPR30 but lacks Estrogen Receptor alpha or beta. Keywords: Gene expression analysis, Non-genomic signali...
ORGANISM(S): Homo sapiens 
2009-02-19 | E-GEOD-11567 | biostudies-arrayexpress
GenomicsEffect of depletion of GPR30 on gene expression in female C57BL/6J mice
Effect of depletion of GPR30 on gene expression in female C57BL/6J mice
PRJNA877835 | ENA
TranscriptomicsEffect of depletion of GPR30 on gene expression in female C57BL/6J mice
To test the cell-specific function of GPR30 in learning and memory, we generated global GPR30 knockout (KO) mice (Δ3102), astrocyte-specific GPR30 KO (AG-KO) mice and neuron-specific GPR30 KO (NG-KO) mice. We found that GPR30 in astrocytes but not neurons is required to maintain normal learning and ...
ORGANISM(S): Mus musculus 
2023-08-10 | GSE212893 | GEO
ModelsRouhimoghadam2018 - GPR30/PI3K/MAPK/STAT signaling pathway in normal and cancer cells
In the current study, we aimed to simulate the GPR30/PI3K/MAPK/STAT signaling pathway in normal and cancer cells by the use of ordinary differential equation modeling. In addition, we planned to show that MAPK activation pattern is different between normal and cancer models.
2018-07-12 | MODEL1807040001 | BioModels
ModelsRouhimoghadam2018 - GPR30/PI3K/MAPK/STAT signaling pathway in normal and cancer cells
In the current study, we aimed to simulate the GPR30/PI3K/MAPK/STAT signaling pathway in normal and cancer cells by the use of ordinary differential equation modeling. In addition, we planned to show that MAPK activation pattern is different between normal and cancer models.
2020-03-16 | MODEL2002250001 | BioModels
TranscriptomicsThe effect of GPR30 agonist G-1 on androgen-sensitive and castration-resistant LNCaP xenografts
G-1 is an agonist to GPR30. Activation of GPR30 by G-1 inhibited prostate cancer cell growth in LNCaP xenografts regrown after catration of the host (nude mice), but not in the androgen-sensitive LNCaP xenograft grown in an intact host. Results provide insights into the molecular basis of G-1 action...
ORGANISM(S): Homo sapiens 
2014-02-14 | E-GEOD-54974 | biostudies-arrayexpress
ProteomicsQuantitative phosphoproteomics of chronic sunitinib treated renal cell carcinoma 786-O cells with GPR30 agonist G-1
In this project, we generated chronic sunitinib-treated 786-O cell, a renal cell carcinoma cell line. In order to investigate the possible effect of GPR30 agonist, G-1, on the growth-inhibtion related signaling pathways, we treated either parental both parental and chronic sunitinib-treated 786-O ce...
ORGANISM(S): Homo sapiens (Human) 
2021-04-28 | PXD021254 | Pride
Renal cell carcinoma Sunitinib Gpr30 
UnknownActivation of GPR30 inhibits cardiac fibroblast proliferation.
Not available
S-EPMC4449333 | biostudies-literature
GenomicsGPR30-mediated NETs degradation via Trex1 in heart failure of aged female mice
GPR30-mediated NETs degradation via Trex1 in heart failure of aged female mice
PRJNA1431941 | ENA
TranscriptomicsGPR30-mediated estrogen signaling in Estrogen Receptor alpha and beta negative SKBR3 breast cancer cells
Gene expression analyses were carried out to identify genes regulated by 17-beta estradiol (E2) and Hydroxytamoxifen (OHT) through GPR30 in SKBR3 cells, a breast cancer cell-line which expresses GPR30 but lacks Estrogen Receptor alpha or beta. Keywords: Gene expression analysis, Non-genomic signalin...
ORGANISM(S): Homo sapiens 
2009-02-19 | GSE11567 | GEO
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