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GenomicsIdentification and Characterization of Enhancers Controlling the Inflammatory Gene Expression Program in Macrophages
Enhancers determine tissue-specific gene expression programs. Enhancers are marked by high histone H3 lysine 4 mono-methylation (H3K4me1) and by the acetyl-transferase p300, which has allowed genome-wide enhancer identification. However, the regulatory principles by which subsets of enhancers become...
ORGANISM(S): Mus musculus 
2010-03-05 | E-GEOD-19553 | biostudies-arrayexpress
MetabolomicsTheabrownin from Pu-erh tea attenuates hypercholesterolemia via modulation of gut microbiota and bile acid metabolism
Pu-erh tea displays cholesterol-lowering properties, but the underlying mechanism has not been elucidated. Theabrownin is one of the most active and abundant pigments in Pu-erh tea. Here, we show that theabrownin alters the gut microbiota in mice and humans, predominantly suppressing microbes associ...
2021-11-18 | MTBLS1259 | MetaboLights
MetabolomicsPu-erh tea and theabrownin ameliorate metabolic syndrome in mice via potential microbiota-gut-liver-brain interactions
Metabolic syndrome (MS) is a common metabolic disorder characterized by obesity, insulin resistance, cardiovascular disease and gut microbiota dysbiosis. Pu-erh tea and its ingredient theabrownin have known functions on the reduction of body weight gain and fat accumulation. However, few studies sys...
2024-09-25 | MTBLS2594 | MetaboLights
GenomicsTwo distinct auto-regulatory loops operate at the Pu.1 locus in B cells and myeloid cells
The transcription factor PU.1 occupies a central role in controlling myeloid and early B cell development and its correct lineage-specific expression is critical for the differentiation choice of hematopoietic progenitors. However, little is known of how this tissue-specific pattern is established. ...
ORGANISM(S): Mus musculus 
2011-02-21 | E-GEOD-26550 | biostudies-arrayexpress
UnknownImmobilization of laccase onto modified PU/RC nanofiber via atom transfer radical polymerization method and application in removal of bisphenol A.
Not available
S-EPMC6999588 | biostudies-literature
UnknownFolate-modified biomimetic nanovesicles loaded with a PU.1 inhibitor alleviate atherosclerosis by suppressing inflammation.
Not available
S-EPMC12797845 | biostudies-literature
UnknownPositive regulatory domain I (PRDM1) and IRF8/PU.1 counter-regulate MHC class II transactivator (CIITA) expression during dendritic cell maturation.
Not available
S-EPMC3048676 | biostudies-literature
UnknownUSP22 deficiency leads to myeloid leukemia upon oncogenic Kras activation through a PU.1-dependent mechanism.
Not available
S-EPMC6071563 | biostudies-literature
UnknownAuthentication of Acori Tatarinowii Rhizoma (Shi Chang Pu) and its adulterants by morphological distinction, chemical composition and ITS sequencing.
Not available
S-EPMC5037583 | biostudies-literature
UnknownPolyurethane-P2S5 composite-based solid-state electrolyte assists low polarization and high stability all-solid-state lithium-ion batteries.
Not available
S-EPMC9520676 | biostudies-literature
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