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TranscriptomicsExpression Profiling of Tissues versus Primary Cultures from Colorectal Cancer Patients
The main aim of this study is to evaluate how comparable the established colorectal primary tumor cultures are to the original tumor tissues obtained directly from patients in terms of their genomic profile for which they can be eventually utilized to improve in vitro drug assessment and facilitate ...
ORGANISM(S): Homo sapiens 
2011-05-29 | E-GEOD-24993 | biostudies-arrayexpress
TranscriptomicsRegulation of hTERT by BCR-ABL at multiple levels in K562 cells
To investigate the mechanism of telomerase regulation in BCR-ABL positive cells due to its clinical value, we studied the catalytic component of telomerase, TERT. Our results suggest that BCR-ABL plays an important role in regulating hTERT in K562 (BCR-ABL positive human leukemia) cells. When Gleeve...
ORGANISM(S): Homo sapiens 
2011-12-15 | E-GEOD-26821 | biostudies-arrayexpress
TranscriptomicsInvestigation of extra-telomeric effects of hTERT in neoplastic transformation of IMR90 cells
The complexity and heterogeneity of cancer cells are under-represented by the current experimental models which revolve around primary tumor cells, cancer cell lines, and rodent models. We used the transformed cell model in our studies. IMR90 and BJ fibroblast cells were transformed by three oncogen...
ORGANISM(S): Homo sapiens 
2010-12-31 | E-GEOD-24097 | biostudies-arrayexpress
TranscriptomicsMutated RNA component of the telomerase induces apoptosis via GADD45-? in hTERT-overexpressing primary fibroblasts
Mutant template human telomerase RNAs (MT-hTers) have been shown to induce apoptosis in various cancerous cells that have high telomerase activity. However, the exact mechanisms by which MT-hTers inhibit the growth of cancer cells and affect normal somatic cells remain largely unknown. To determine ...
ORGANISM(S): Homo sapiens 
2011-05-28 | E-GEOD-24975 | biostudies-arrayexpress
ProteomicsProteome of uterine cavity fluid in female rattus
The injection with GnIH/saline through the lateral ventricle. At 6 h after injection, the protein components of rats in the experimental and control groups were analyzed using Liquid Chromatography (LC)-Mass Spectrometry (MS)/MS.
ORGANISM(S): Rattus Rattus 
2022-10-31 | PXD037826 |
ProteomicsA chemical screen identifies PRMT5 as a therapeutic vulnerability for paclitaxel-resistant triple-negative breast cancer
Through chemical probe screening, we uncovered a novel mechanism of RNA splicing in paclitaxel-resistant TNBC and identified PRMTs as therapeutic targets.
ORGANISM(S): Homo Sapiens 
PXD053336 |
ProteomicsRegulation of the PKD2 channel function and associated disease phenotypes by RASSF4
Autosomal dominant polycystic kidney disease (ADPKD) is one of the most common monogenic genetic disorders, caused by mutations in receptor PKD1 or ion channel PKD2, and is characterized by progressive renal cyst development with additional hepatic and extrarenal manifestations. As effective treatme...
ORGANISM(S): Homo Sapiens 
2026-02-13 | PXD074819 |
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