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MetabolomicsGastropods and Insects Prefer Different Solanum dulcamara Chemotypes
Solanum dulcamara (Bittersweet nightshade) shows significant intraspecific variation in glycoalkaloid (GA) composition and concentration. We previously showed that constitutive differences in overall GA levels are correlated with feeding preference of the grey field slug (GFS; Deroceras reticulatum)...
2020-05-16 | MTBLS1132 | MetaboLights
MetabolomicsGlycoalkaloid composition explains variation in slug resistance in Solanum dulcamara
In natural environments, plants have to deal with a wide range of different herbivores whose communities vary in time and space. It is believed that the chemical diversity within plant species has mainly arisen from selection pressures exerted by herbivores. So far, the effects of chemical diversity...
2019-06-17 | MTBLS738 | MetaboLights
UnknownCan a Wanzlick-like equilibrium exist between dicoordinate borylenes and diborenes?
Not available
S-EPMC9093173 | biostudies-literature
MetabolomicsCascading effects of root microbial symbiosis on the development and metabolome of the insect herbivore Manduca sexta L

Root mutualistic microbes can modulate the production of plant secondary metabolites affecting plant–herbivore interactions. Still, the main mechanisms underlying the impact of root mutualists on herbivore performance remain ambiguous. In particular, little is known about how changes in the plant...

2023-09-12 | MTBLS2700 | MetaboLights
MetabolomicsPlot diversity differentially affects the chemical composition of leaves, roots and root exudates in four subtropical tree species

Plants produce thousands of compounds, collectively called the metabolome, which mediate interactions with other organisms. The metabolome of an individual plant may change according to the number and nature of these interactions. We tested the hypothesis that tree diversity level affects the met...

2021-08-09 | MTBLS1968 | MetaboLights
UnknownPodocyte-Specific Sialylation-Deficient Mice Serve as a Model for Human FSGS.
Not available
S-EPMC6551790 | biostudies-literature
MetabolomicsPlant species richness elicits changes in the metabolome of grassland species via soil biotic legacy
Species-rich plant communities can induce unique soil biotic legacy effects through changing the abundance and composition of soil biota. These soil legacy effects can cause feedbacks to influence plant performance. In addition, soil biota can induce (defensive) secondary metabolites in shoots ...
2019-05-30 | MTBLS544 | MetaboLights
UnknownPLCG2 protective variant p.P522R modulates tau pathology and disease progression in patients with mild cognitive impairment.
Not available
S-EPMC7244617 | biostudies-literature
ModelsChowell2022 - Random Forest model to predict efficacy of immune checkpoint blockade across multiple cancer patient cohorts
This is a Random Forest algorithm-based machine learning model called RF16, which incorporates a total of 16 genomic, molecular, demographic, and clinical features to predict the immunotherapy response for a patient. The model assigns a value of 0 for NonResponder and 1 for Responder. Please be awar...
2023-05-09 | BIOMD0000001066 | BioModels
Machine Learning Model FAIR-AIML 
ModelsDiego2021 - Improved Prediction of ICB Efficacy Across Multiple Cancer Types using Random Forests
In this study, the authors had developed a machine learning model to predict immune checkpoint blockade (ICB) response by integrating genomic, molecular, demographic and clinical data from a curated cohort (MSK-IMPACT) with 1479 patients treated with ICB across 16 different types of cancer. This mod...
2024-07-23 | MODEL2407210002 | BioModels
Machine Learning Model 
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