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TranscriptomicsUnlinking a lncRNA from its associated cis element [gene expression]
Transcriptome analysis of effect of Lockd knockout on cells Many long non-coding (lnc) RNAs are reported to regulate gene expression and protein functions. However, the proportion of lncRNAs with biological activities among the thousands expressed in mammalian cells is controversial. We studied Lock...
ORGANISM(S): Mus musculus 
2016-06-01 | E-GEOD-75449 | biostudies-arrayexpress
TranscriptomicsMicroRNA expression during murine fetal liver megakaryocyte differentiation
MicroRNAs are small non-coding RNAs that regulate cellular development by interfering with mRNA stability and translation. We defined the kinetics of global microRNA expression during the differentiation of murine hematopoietic progenitors into megakaryocytes. Of 435 miRNAs analyzed, 13 were upreg...
ORGANISM(S): Mus musculus 
2010-12-07 | E-GEOD-22480 | biostudies-arrayexpress
TranscriptomicsTranscriptome analysis of miR-144/451-null bone marrow erythroid cells
microRNA miR-144/451 is highly expressed during erythropoiesis. We deleted the miR-144/451 gene locus in mice and compared the transcriptomes of miR-144/451-null bone marrow erythroid precursors to stage-matched wild-type control cells. Ter119+/CD71+/FSC-high bone marrow erythroblasts were sorted di...
ORGANISM(S): Mus musculus 
2010-07-15 | E-GEOD-21041 | biostudies-arrayexpress
TranscriptomicsLong noncoding RNA expression in several hematopoietic progenitor and differentiated cell populations using a custom Agilent microarray
Mammals express thousands of long noncoding (lnc) RNAs, a few of which are shown to function in tissue development. However, the entire repertoire of lncRNAs and the extent to which they regulate biological processes in different tissues and species are not defined. Indeed, most lncRNAs are not cons...
ORGANISM(S): Mus musculus 
2014-02-20 | E-GEOD-51892 | biostudies-arrayexpress
MetabolomicsSCP4-STK35/PDIK1L complex is a dual phospho-catalytic signaling dependency in acute myeloid leukemia
Acute myeloid leukemia (AML) cells rely on phospho-signaling pathways to gain unlimited proliferation potential. Here, we used domain-focused CRISPR screening to identify the nuclear phosphatase SCP4 as a dependency in AML, yet this enzyme is dispensable in normal hematopoietic progenitor cells. Usi...
2025-05-29 | MTBLS3707 | MetaboLights
GenomicsGenome-wide maps of epigenetic features in G1E model and in mouse primary erythroblasts.
Interplays among lineage specific nuclear proteins, chromatin modifying enzymes and the basal transcription machinery govern cellular differentiation, but their dynamics of actions and coordination with transcriptional control are not fully understood. Alterations in chromatin structure appear to es...
ORGANISM(S): Mus musculus 
2011-07-05 | E-GEOD-30142 | biostudies-arrayexpress
UnknownCommunity-Based, Point-of-Care Sexually Transmitted Infection Screening Among High-Risk Adolescents in Los Angeles and New Orleans: Protocol for a Mixed-Methods Study.
Not available
S-EPMC6450482 | biostudies-literature
UnknownThe Stepped Care Intervention to Suppress Viral Load in Youth Living With HIV: Protocol for a Randomized Controlled Trial.
Not available
S-EPMC6414817 | biostudies-literature
Unknown20-Year Risks of Breast-Cancer Recurrence after Stopping Endocrine Therapy at 5 Years.
Not available
S-EPMC5734609 | biostudies-literature
UnknownText-Messaging, Online Peer Support Group, and Coaching Strategies to Optimize the HIV Prevention Continuum for Youth: Protocol for a Randomized Controlled Trial.
Not available
S-EPMC6707028 | biostudies-literature
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