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TranscriptomicsIntegrative phenotypic and transcriptomic validation of an alveolar-like macrophage model reveals early host–pathogen dynamics during Aspergillus fumigatus infection
The saprophytic mold Aspergillus fumigatus produces small (2-3 µm) airborne spores (conidia) that can reach the lung alveoli upon inhalation. There, they encounter the surfactant-rich environment of the alveolar epithelium and initiate swelling and germination. Primary alveolar macrophages are essen...
ORGANISM(S): Homo sapiens 
2026-10-02 | E-MTAB-17130 | biostudies-arrayexpress
TranscriptomicsUnveiling immune interference: How dendritic cell response to co-infection with Aspergillus fumigatus is modulated by human cytomegalovirus and its virokine CMVIL10
We confronted moDCs with wildtype (WT) HCMV TB40E BAC4 or ΔUL111A (HCMV lacking CMVIL-10) with an MOI of 3 and/or A. fumigatus germ tubes with an MOI of 0.5 for 9 h, either individually (single infection) or simultaneously (co-infection), and performed RNA-seq. moDCs were incubated with or without 5...
ORGANISM(S): Homo sapiens 
2025-09-09 | E-MTAB-15110 | biostudies-arrayexpress
ModelsMirhakkakSchaeuble2021 - a Candida albicans genome-scale metabolic model reconstruction
A genome-scale metabolic model (GEM) of C. albicans was reconstructed and curated by using phenotypic microarray data and resolving erroneous energy-generating cycles. It comprises 771 genes, 3082 metabolic reactions and 2733 metabolites. In Mirhakkak et al. 2021 (https://doi.org/10.1038/s41396-020-...
2023-04-25 | MODEL2110210002 | BioModels
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