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TranscriptomicsTranscription profiling of Jurkat T cell line and mouse thymocytes
Signal transduction pathways guided by cellular receptors commonly exhibit low-level constitutive signaling in a continuous, ligand-independent manner. The dynamic equilibrium of positive and negative regulators establishes such a tonic signal. Ligandindependent signaling by the precursors of mature...
ORGANISM(S): Homo sapiens 
2005-10-14 | E-SMDB-2194 | biostudies-arrayexpress
TranscriptomicsEarly-induced genes of human regulatory CD4+CD25hi Treg and CD4+CD25- Th cells
Goals and objectives of this study: to identify genes preferentially induced in human CD4+CD25hi Treg cells following T-cell activation with potential role for stabililization & maintenance of the regulatory program. Keywords: T-cell receptor stimulation, gene-regulation, comparative gene expressio...
ORGANISM(S): Homo sapiens 
2009-04-20 | E-GEOD-13017 | biostudies-arrayexpress
UnknownGenetic T-type calcium channelopathies.
Not available
S-EPMC6929700 | biostudies-literature
ProteomicsThe catalytic activity of the kinase Zap-70 mediates basal signaling and negative feedback of the T cell receptor pathway
T cell activation must be properly regulated to ensure normal T cell development and effective immune responses to pathogens and transformed cells, while avoiding autoimmunity. Our knowledge of the mechanisms controlling the fine-tuning of T cell receptor (TCR) signaling and T cell activation is sti...
ORGANISM(S): Homo sapiens (Human) 
2016-05-31 | PXD002023 | Pride
T cell Phosphoproteomics Lc-ms/ms 
TranscriptomicsHuman activated Treg cells and retrovirally engineered Th cells, transduced with GARP, FOXP3 or control GFP vector
Goals and objectives of this study: to identify genes of the Treg signature induced by consitutive expression of GARP or FOXP3 in antigen-specific Th cells with potential role for stabililization & maintenance of the regulatory program. Keywords: T-cell receptor stimulation, gene-regulation, compar...
ORGANISM(S): Homo sapiens 
2009-04-20 | E-GEOD-13234 | biostudies-arrayexpress
TranscriptomicsGene expression analysis of iTregs and nTregs
MBP TCR Tg mouse (1B3) generates only iTregs when crossed onto RAGKO background. Tregs from 1B3.RAG mouse were used for gene expression analsysis to determine genes selectively expressed in peripherally generated iTregs iTregs from 1B3.RAG mice (>90% Foxp3+) were run against total Tregs from 1B3 and...
ORGANISM(S): Mus musculus 
2013-07-03 | E-GEOD-39724 | biostudies-arrayexpress
GenomicsRNA sequencing of T cells in the genetically encoded mouse model of T cell anergy (W131AOTII)
RNA sequencing of T cells in the genetically encoded mouse model of T cell anergy (W131AOTII)
PRJNA703544 | ENA
UnknownThe Prognostic Role of CD8+ T Lymphocytes in Childhood Adrenocortical Carcinomas Compared to Ki-67, PD-1, PD-L1, and the Weiss Score.
Not available
S-EPMC6896110 | biostudies-literature
TranscriptomicsTranscription profiling of human Th cells expressing Foxp3 and UBD ectopically
Expression analysis revealed that UBD is a down-stream element of Foxp3 in human activated regulatory CD4+ T cells (Treg). Experiment Overall Design: Comparison of expression profiles measured in naturally occuring regulatory T-cells (Treg), Foxp3 and UBD transformed Th cells versus their controls w...
ORGANISM(S): Homo sapiens 
2008-06-13 | E-GEOD-4527 | biostudies-arrayexpress
UnknownLoss of Neurological Disease HSAN-I-Associated Gene SPTLC2 Impairs CD8<sup>+</sup> T Cell Responses to Infection by Inhibiting T Cell Metabolic Fitness.
Not available
S-EPMC6531359 | biostudies-literature
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