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TranscriptomicsGene expression in clonogenic versus non-clonogenic in pooled early passage OCI/AML-4 single cells
Identification of genes that regulate clonogenicity of AML cells is hindered by the difficulty of isolating pure populations of cells with defined proliferative abilities. Using early passages of the OCI/AML-4 cell line we sought to determine genes differentially expressed between clonogenic and no...
ORGANISM(S): Homo sapiens 
2011-06-01 | E-GEOD-28612 | biostudies-arrayexpress
TranscriptomicsEpigenetic events in early breast cancer
Subpopulations of primary Human Mammary Epithelial Cells (HMEC) have the unique ability to escape a period of growth arrest and continue to proliferate. These cells, called post-selection or variant cells (vHMEC), share features with premalignant breast cancer lesions, including p16INK4A promoter h...
ORGANISM(S): Homo sapiens 
2010-05-26 | E-GEOD-8007 | biostudies-arrayexpress
TranscriptomicsMesenchymal stromal cells isolated from bronchoalveolar lavage and digest parenchymal lung tissue
Stromal support is critical to the achievement of lung homeostasis and the maintenance of an effective epithelial barrier, and yet previous studies have found a positive association between the number of mesenchymal stromal cell populations (MSCs) isolated from the alveolar space and human diseases ...
ORGANISM(S): Homo sapiens 
2016-07-04 | E-GEOD-74284 | biostudies-arrayexpress
TranscriptomicsExpression data from MSC-treated monocytes
Chronic inflammation leading to pro-inflammatory macrophage infiltration contributes to the pathogenesis of type 2 diabetes and subsequently the development of diabetic nephropathy. Mesenchymal stem cells (MSCs) possess unique immunomodulatory and cytoprotective properties making them an ideal candi...
ORGANISM(S): Homo sapiens 
2015-11-10 | E-GEOD-65561 | biostudies-arrayexpress
MetabolomicsProMetIS, deep phenotyping of mouse models by combined proteomics and metabolomics analysis

Genes are pleiotropic and getting a better knowledge of their function requires a comprehensive characterization of their mutants. Here, we generated multi-level data combining phenomic, proteomic and metabolomic acquisitions from plasma and liver tissues of two C57BL/6 N mouse models lacking the...

2021-09-01 | MTBLS1903 | MetaboLights
TranscriptomicsMacrophage response to lipopolysaccharide
Temporal analysis of bone marrow derived macrophages after 10 ug/ml lipopolysaccharide stimulation. C57BL6, C3H/ARC, BalbC and C3H/HeJ mouse strains analyzed. Each time point stimulated with 10ug/ml LPS from Salmonella minnesota for the time indicated. The RNA from each BMM stimulated time point was...
ORGANISM(S): Mus musculus 
2010-07-01 | E-GEOD-3148 | biostudies-arrayexpress
TranscriptomicsBMM_C3H/HeJ_LPS_timecourse
Bone marrow derived macrophages (BMM) total RNA from C3H/ARC mice extracted after stimulation by LPS at different time points. Each time point stimulated with 10ug/ml LPS from Salmonella minnesota for the time indicated. The RNA from each BMM stimulated time point was labeled with Cy3 and compared w...
ORGANISM(S): Mus musculus 
2010-06-05 | E-GEOD-326 | biostudies-arrayexpress
TranscriptomicsBMM_BalbC_LPS_timecourse
Bone marrow derived macrophages (BMM) total RNA from C3H/ARC mice extracted after stimulation by LPS at different time points. Each time point stimulated with 10ug/ml LPS from Salmonella minnesota for the time indicated. The RNA from each BMM stimulated time point was labeled with Cy3 and compared w...
ORGANISM(S): Mus musculus 
2003-03-27 | E-GEOD-325 | biostudies-arrayexpress
TranscriptomicsBMM_C3H/ARC_LPS_timecourse
Bone marrow derived macrophages (BMM) total RNA from C3H/ARC mice extracted after stimulation by LPS at different time points. Each time point stimulated with 10ug/ml LPS from Salmonella minnesota for the time indicated. The RNA from each BMM stimulated time point was labeled with Cy3 and compared w...
ORGANISM(S): Mus musculus 
2010-06-05 | E-GEOD-324 | biostudies-arrayexpress
TranscriptomicsPromiscuous targeting of bromodomains by Bromosporine identifies BET proteins as master regulators of primary transcription response in leukemia [set 1]
Bromodomains (BRDs) have emerged as compelling targets for cancer therapy. The development of selective and potent BET inhibitors and their significant activity in diverse tumor models has rapidly translated into clinical studies and has motivated drug development efforts targeting non-BET BRDs. How...
ORGANISM(S): Homo sapiens 
2016-10-25 | E-GEOD-78827 | biostudies-arrayexpress
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