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ProteomicsNdfip1 restricts mTORC1 signalling and glycolysis in regulatory T cells to prevent autoinflammatory disease
Project abstract: Foxp3+ T regulatory (Treg) cells have important functions in suppressing immune cell activation and establishing normal immune homeostasis. How Treg cells maintain their identity is not completely understood. Here we show that Ndfip1, a co-activator of Nedd4-family E3 ubiquitin lig...
ORGANISM(S): Mus musculus (Mouse) 
2017-04-19 | PXD006251 | Pride
Effector-type regulatory t cells (etreg cells) Ndfip1 Central regulatory t cells (ctreg cells) Regulatory t cells (treg cells) 
TranscriptomicsMapping T cell responses to native and neo- islet antigen epitopes in at risk and type 1 diabetes subjects
Gene expression and T cell receptor profiles from single cells from populations of T cells stimulated with islet autoantigenic peptides. CD4 T cells were stimulated with native (proinsulin, GAD fragments) or neo-antigen epitopes or flu vaccine (Pediacel). Activated cells (identified as CD19- CD3+ C...
ORGANISM(S): Homo sapiens 
2021-05-29 | E-MTAB-10323 | biostudies-arrayexpress
UnknownBallistic superconductivity and tunable π-junctions in InSb quantum wells.
Not available
S-EPMC6704170 | biostudies-literature
UnknownIkaros silences T-bet expression and interferon-gamma production during T helper 2 differentiation.
Not available
S-EPMC2807311 | biostudies-literature
UnknownRegulatory T cells suppress CD4+ T cells through NFAT-dependent transcriptional mechanisms.
Not available
S-EPMC4198043 | biostudies-literature
UnknownFoxp3 depends on Ikaros for control of regulatory T cell gene expression and function.
Not available
S-EPMC11042806 | biostudies-literature
TranscriptomicsInduction of the IL-9 gene by HTLV-I Tax stimulates the spontaneous proliferation of primary adult T-cell leukemia cells
The mechanism whereby IL-9 stimulated monocytes, promote proliferation of co-cultured ATL cells remains undefined. To obtain preliminary clues concerning this contribution, transcription profiles were obtained between monocytes derived from ATL patients and those derived from healthy donors as asses...
ORGANISM(S): Homo sapiens 
2010-05-25 | E-GEOD-10789 | biostudies-arrayexpress
UnknownRegulatory T cell subsets in patients with medulloblastoma at diagnosis and during standard irradiation and chemotherapy (PBTC N-11).
Not available
S-EPMC5677543 | biostudies-literature
TranscriptomicsMbd2 promotes Foxp3 demethylation and T-regulatory cell function
The proposed use of Foxp3+ T-regulatory (Treg) cells as potential cellular therapy in patients with autoimmune diseases, or post-hemopoietic stem cell or organ transplantation, requires a sound understanding of the transcriptional regulation of Foxp3 expression. Conserved CpG dinucleotides in the Tr...
ORGANISM(S): Mus musculus 
2013-09-01 | E-GEOD-48653 | biostudies-arrayexpress
UnknownPTEN directs developmental and metabolic signaling for innate-like T cell fate and tissue homeostasis.
Not available
S-EPMC10080469 | biostudies-literature
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