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TranscriptomicsWnt and FGF signals interact to coordinate growth with cell fate specification during limb development
A fundamental question in biology is how an undifferentiated field of cells acquires spatial pattern and undergoes coordinated differentiation. The development of the vertebrate limb is an important paradigm for understanding these processes. The skeletal and connective tissues of the developing lim...
ORGANISM(S): Mus musculus 
2010-05-25 | E-GEOD-12441 | biostudies-arrayexpress
TranscriptomicsSingle-cell RNA-seq of tailbuds from control, Pbx1/Pbx2 compound and Pbx1/Pbx2 double-knockout E8.5/E9.0 embryos.
In vertebrates, body axis elongation is fuelled by bipotent neuromesodermal progenitors (NMPs), which support the development of both spinal cord and paraxial mesoderm (PM). NMPs reside in the caudal lateral epiblast and tailbud, from where they sustain axial elongation. HOX transcription factors ha...
ORGANISM(S): Mus musculus 
2021-07-21 | E-MTAB-9785 | biostudies-arrayexpress
Transcriptomics21T series cell lines show distinct stage-specific gene expression alterations
Pathologic and epidemiologic evidence has led to a histologic model of breast cancer progression that involves advancement through specific morphologic stages including atypical ductal hyperplasia (ADH), ductal carcinoma in situ (DCIS) and invasive mammary carcinoma (IMC), although not necessarily a...
ORGANISM(S): Homo sapiens 
2010-04-06 | E-GEOD-18370 | biostudies-arrayexpress
TranscriptomicsCellular response to protein-conjugated nanoparticles
Interaction of nanomaterials with the mammalian cells remains to be poorly understood at the molecular level. Here we report the first synthesis of hybrid nanomaterial termed phage mimetic nanorods (PMN’s) inspired from filamentous bacteriophage present in nature. We emulate filamentous bacteriophag...
ORGANISM(S): Homo sapiens 
2011-12-31 | E-GEOD-23118 | biostudies-arrayexpress
TranscriptomicsComparison of seven single cell Whole Genome Amplification commercial kits using targeted sequencing
Advances in biochemical technologies have led to a boost in the field of single cell genomics. Observation of the genome at a single cell resolution is currently achieved by pre-amplification using whole genome amplification (WGA) techniques that differ by their biochemical aspects and as a result b...
ORGANISM(S): Homo sapiens 
2017-09-24 | E-MTAB-5968 | biostudies-arrayexpress
TranscriptomicsA comprehensive and universal method for assessing the performance of differential gene expression analyses
The number of methods for pre-processing and analysis of gene expression data continues to increase, often making it difficult to select the most appropriate approach. We present a simple procedure for the comparative estimation of a variety of methods for microarray data pre-processing and analysis...
ORGANISM(S): Homo sapiens 
2010-11-09 | E-GEOD-22630 | biostudies-arrayexpress
TranscriptomicsCelecoxib induced transcriptional alterations in gastric cancer cells
Celecoxib is recognized to have chemopreventive and anti-cancer property beyond its anti-inflammatory function. Celelcoxib treatment in AGS cells down regulates Wnt/M-NM-2-catenin, STAT3, RXR and ERK/MAPK signaling pathways. Transcriptional profiling after celecoxib shows differential regulation of ...
ORGANISM(S): Homo sapiens 
2014-04-01 | E-GEOD-54657 | biostudies-arrayexpress
TranscriptomicsFn multispecies biofilm experiment
This study was conducted to identify whether F. nucleatum has species or group specific transcriptional responses by analyzing dual species biofilms containing either early or late colonizers and utilizing microarrays to identify altered gene expression of F. nucleatum.
ORGANISM(S): Fusobacterium nucleatum 
2011-11-30 | E-MEXP-3058 | biostudies-arrayexpress
UnknownFactors associated with corneal graft survival in the cornea donor study.
Not available
S-EPMC4394864 | biostudies-literature
UnknownDenosumab in men receiving androgen-deprivation therapy for prostate cancer.
Not available
S-EPMC3038121 | biostudies-literature
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