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TranscriptomicsComparative analysis of gene expression in response to LL-37 treatment
To identify the potential LL-37-responsed genes, we treated cells with or without LL-37 and their correspondent transcriptional profiles were compared. Total 104 significant genes were identified. Among them, 70 genes are upregulated in repsonse to LL-37 while 34 genes are downregulated in compariso...
ORGANISM(S): Candida albicans 
2016-03-11 | E-GEOD-45177 | biostudies-arrayexpress
TranscriptomicsMolecular mechanism underline immune cell type population shift upon anti-DLL4 treatment
Molecular mechanism underline immune cell type population shift upon anti-DLL4 treatment C57BL/6 mice were injected with anti-DLL4, or an isotype control antibody as controls. Two weeks later mice were sacrificed, and thymi was harvested from 4 anti-DLL4 and 4 control animals. Total thymocytes, DN c...
ORGANISM(S): Mus musculus 
2012-04-29 | E-GEOD-24296 | biostudies-arrayexpress
TranscriptomicsGene expression in early phases of Autosomal Dominant Polycystic Kidney Disease
Little is known about the genes involved in the initial cyst formation and disease progression in autosomal dominant polycystic kidney disease (ADPKD). To uncover the genetic determinants and molecular mechanisms of ADPKD, we analyzed 4-point time-series DNA microarrays from Pkd1L3/L3 mice to genera...
ORGANISM(S): Mus musculus 
2008-12-28 | E-GEOD-13452 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse intestinal epithelial spheroids cultured as stem cells, wound-associated epithelial cells or enterocytes
Intestinal epithelial spheroids were isolated from mouse jejunum as described in our previous publication (Miyoshi and Stappenbeck. In vitro expansion and genetic modification of gastrointestinal stem cells in spheroid culture. Nature Protocols. 2013. PMID: 24232249) and then grown in 50% L-WRN cond...
ORGANISM(S): Mus musculus 
2016-10-25 | E-MTAB-3952 | biostudies-arrayexpress
GenomicsSingle Cell triple omics sequencing reveals genetic and epigenetic heterogeneity in hepatocellular carcinoma
Single cell genome, DNA methylome, and transcriptome sequencing has been achieved separately. However, to analyze the regulation of RNA expression by genetic and epigenetic factors within an individual cell, it is necessary to analyze these omics simultaneously from the same single cell. Here we dev...
ORGANISM(S): Mus musculus 
2016-03-01 | E-GEOD-65364 | biostudies-arrayexpress
TranscriptomicsZebrafish 22 hpf embryos: WT vs. MO-grnA injected
Transcriptional profiling of zebrafish embryos comparing wild type untreated embryos with embryos injected with morpholino of zf-grna. This assay is used for the determination of expression profiling at 22 hpf under GRN-A deficiency. Two-condition experiment: wild type vs. MO-grnA treated cells. 3 b...
ORGANISM(S): Danio rerio 
2013-03-28 | E-GEOD-28318 | biostudies-arrayexpress
TranscriptomicsAntibody detection of translocations (ADOT) in Ewing Sarcoma
We developed a new approach called antibody detection of translocations (ADOT) which combines a transcriptional microarray-based approach with a novel antibody-based detection method to detect translocations in cancer. ADOT allows for the accurate and sensitive identification of translocations and p...
ORGANISM(S): Homo sapiens 
2012-01-31 | E-GEOD-35450 | biostudies-arrayexpress
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