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UnknownGenome-wide association study reveals novel genetic determinants of DNA repair capacity in lung cancer.
Not available
S-EPMC3537906 | biostudies-literature
MetabolomicsPRODH regultes naive pluripotency by influencing mitochondrial oxidative phosphorylation (Targeted metabolomics)

Naïve human embryonic stem cells (hESCs) that resemble the pre-implantation epiblasts are fueled by a combination of aerobic glycolysis and oxidative phosphorylation, but their mitochondrial regulators are poorly understood. Here we report that, proline dehydrogenase (PRODH), a mitochondria-local...

2024-02-12 | MTBLS7832 | MetaboLights
UnknownEvolutionarily conserved protein ERH controls CENP-E mRNA splicing and is required for the survival of KRAS mutant cancer cells.
Not available
S-EPMC3535619 | biostudies-literature
GenomicsWhole-Genome and Epigenomic Landscapes of Etiologically Distinct Subtypes of Cholangiocarcinoma
Cholangiocarcinoma (CCA) is a hepatobiliary malignancy exhibiting high incidence in countries with endemic liver-fluke infection. We analyzed 489 CCAs from 10 countries, combining whole-genome (71 cases), targeted/exome, copy-number, gene expression, and DNA methylation information. Integrative clus...
EGAS00001001653 | EGA
UnknownA high-resolution HLA reference panel capturing global population diversity enables multi-ancestry fine-mapping in HIV host response.
Not available
S-EPMC8959399 | biostudies-literature
UnknownNeptune: an environment for the delivery of genomic medicine.
Not available
S-EPMC8487966 | biostudies-literature
UnknownA statistical framework for multi-trait rare variant analysis in large-scale whole-genome sequencing studies.
Not available
S-EPMC11981678 | biostudies-literature
UnknownPowerful, scalable and resource-efficient meta-analysis of rare variant associations in large whole genome sequencing studies.
Not available
S-EPMC10084891 | biostudies-literature
UnknownWhole Genome Association Study of the Plasma Metabolome Identifies Metabolites Linked to Cardiometabolic Disease in Black Individuals.
Not available
S-EPMC9395431 | biostudies-literature
UnknownA framework for detecting noncoding rare-variant associations of large-scale whole-genome sequencing studies.
Not available
S-EPMC10008172 | biostudies-literature
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