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UnknownLack of SIRT1 (Mammalian Sirtuin 1) activity leads to liver steatosis in the SIRT1+/- mice: a role of lipid mobilization and inflammation.
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S-EPMC2875813 | biostudies-literature
Proteomicsthe proteomics of IGFBP6 in endothelial cells (HUVECs)
To unravel the direct mechanism of the anti-inflammatory effects of IGFBP6 in ECs, we analysed HUVECs treated with either adenovirus-Flag-IGFBP6 (Ad-IGFBP6) or control adenovirus (Ad-NC). We precipitated IGFBP6 from overexpressed ECs followed by mass spectrometry.
ORGANISM(S): Homo Sapiens 
PXD052204 |
ProteomicsHepatic LONP1 Overexpression Ameliorates Hepatic Steatosis and Fibrosis in mice
Compared to control mice, liver-specific overexpression of LONP1 alleviated hepatic steatosis and attenuated fibrosis progression in MASH mice. Liver samples from three control mice injected with AAV-3×flag and fed a CDAHFD for 8 weeks were used as the control group, while those from three mice inje...
ORGANISM(S): Mus Musculus 
PXD069474 |
ProteomicsAutophagy and biotransformation affect sorafenib resistance in hepatocellular carcinoma
As a first-line drug for treating advanced hepatocellular carcinoma, the resistance to sorafenib has always attracted attention. However, most attention has been focused on a series of mechanisms related to drug resistance caused after sorafenib treatment. In this study, we used proteomic techniques...
ORGANISM(S): Homo Sapiens 
2023-02-24 | PXD040371 |
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