Chemotherapy resistance is one of the reasons for the loss of the eye in retinoblastoma (RB) pa-tients. RB chemotherapy resistance has been investigated in different cell culture models like WERI RB1. Furthermore, chemotherapy resistant RB subclones like the etoposide resistant WERI ETOR cell line h...
To investigate the role of ELF2 in topotecan resistance, we performed RNA-seq on WERI-Rb1 retinoblastoma cells. Control (NTC) and ELF2-knockout (sgELF2) cells were treated with either vehicle or 30 nM topotecan for 96 hours. Differential gene expression analysis revealed transcriptomic changes assoc...
Fatty acid synthase is a major enzyme involved in de novo lipogenesis and associated with tumor invasion and poor prognosis. The effect of fatty acid synthase knockdown in retinoblastoma cancer cells (WERI RB1) using siRNA mediated gene silencing were accessed for global gene deregulations. The anal...
