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2014 (36)
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CHEBI ID

CHEBI:18012 (4)
CHEBI:16797 (3)
CHEBI:16695 (3)
CHEBI:17562 (3)
CHEBI:15428 (3)
CHEBI:17754 (3)
CHEBI:15741 (3)
CHEBI:16704 (3)
CHEBI:15422 (3)
CHEBI:32816 (3)
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CHEBI:48928 (2)
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CHEBI:17234 (2)

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5-HYDROXYINDOLEACETIC ACID (1)
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IsPrivate

False (2)

First Public Date

2014 (10)
2017 (1)

Modelling Approach

Ordinary differential equation model (2)

Study type

RNA-seq of coding RNA (101)
Transcription profiling by array (88)
ChIP-seq (27)
Other (14)
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Bisulfite-seq (1)
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Methylation profiling by high throughput sequencing (1)

Release Date

2021 (165)
2020 (140)
2022 (136)
2024 (123)
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2015 (96)
2014 (82)
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Lab affiliation

Cellzome (7)
Cellzome, a GSK company (5)
Chromosome dynamics and genome stability, Institute of Epigenetics and Stem Cells, Helmholtz Zentrum München, Feodor-Lynen-Strasse 21, 81377 München, Germany (2)
Department of Human Genetics and Biochemistry Sackler School of Medicine Tel Aviv University Tel-Aviv, Israel 69978 (2)
Department of Medical Biotechnology Faculty of Biochemistry, Biophysics and Biotechnology Jagiellonian University Gronostajowa 7 30-387 Krakow, Poland (2)
1. Wellcome Trust Centre for Cell Biology, University of Edinburgh, Edinburgh EH9 3BF, United Kingdom. 2. Department of Bioanalytics, Institute of Biotechnology, Technische Universität Berlin, 13355 Berlin, Germany. (1)
Cell Biology - Emory University (1)
Dep. of Biology University of Fribourg Chemin du Muséee 10 1700 Fribourg Switzerland (1)
Department of Biotechnology and Biomedicine, Technical University of Denmark (1)
Department of Cell Biology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Poland (1)
Department of Immunology and Microbiology Institute of Biomedicine Sahlgrenska Academy University of Gothenburg (1)
Department of Laboratory Medicine Department of Bioengineering and Therapeutic Sciences University of California, San Francisco (1)
Department of Molecular Systems Biology, Helmholtz Centre for Environmental Research – UFZ, Permoserstraße 15, 04318 Leipzig, Germany (1)
Dept. of Computer Science, University of Tübingen Germany, Center for Bioinformatics, University of Tübingen, Germany, Quantitative Biology Center, University of Tübingen, Germany, Max Planck Institute for Developmental Biology, Germany, (1)
ETH Zurich (1)
Head / Immunopeptidomics unit Department of Oncology UNIL/CHUV Ludwig Cancer Research Center Biopole III, Chemin des Boversses 155 Epalinges, 1066 Switzerland (1)
Insitute for Molecular Medicine and Cell Research, University of Freiburg, Germany (1)
Institute of Biotechnology, Czech Academy of Sciences, Prague-West, Czech Republic. (1)
Institute of Epigenetics and Stem Cells, Helmholtz ZentrumMünchen, Feodor-Lynen- Strasse 21, 81377 München, Germany (1)
Institute of Tumor Biology, University Medical Center Hamburg-Eppendorf Martinistraße 52, 20246 Hamburg, Germany (1)
Institute of molecular virology and cell biology, Laboratory for biochemistry and protein analysis, Friedrich Loeffler Institut, Germany (1)
King Abdullah University of Science & Technology (KAUST), Biological Environmental Sciences and Engineering Division BESE, KAUST Environmental Epigenetics Program, Thuwal, Saudi Arabia. (1)
PD Dr. Olaf Jahn Proteomics Group Max-Planck-Institute of Experimental Medicine Hermann-Rein-Str. 3 37075 Goettingen, Germany Tel: +49-551-3899313 Fax: +49-551-3899323 E-mail: jahn@em.mpg.de URL: www.em.mpg.de/proteomics (1)
Professor Dept. Cell Biology 615 Michael Street Whitehead 446 Atlanta, GA, 30322 Emory University (1)
Professor Dept. Cell Biology Emory University 615 Michael Street Whitehead 446 Atlanta, GA, 30322 (1)
Professor • SOM: Cell Biology Emory University (1)
Professor, Director of Graduate Studies Neuroscience Program Department of Cell Biology, Emory University (1)
Proteomics Group Max Planck Institute of Experimental Medicine Hermann-Rein-Str. 3 37075 Goettingen, Germany Tel: +49-551-3899313 Fax: +49-551-3899323 (1)
Proteomics Group Max-Planck-Institute of Experimental Medicine Hermann-Rein-Str. 3 37075 Goettingen, Germany Tel: +49-551-3899313 Fax: +49-551-3899323 E-mail: jahn@em.mpg.de URL: www.em.mpg.de/proteomics (1)
Research Unit Protein Science, Helmholtz Center Munich, German Research Center for Environmental Health GmbH, Germany (1)

Tags

xref:PubMed:19744757 (8)
xref:PubMed:18757758 (2)

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NAD+ augmentation restores mitophagy and limits accelerated aging in Werner syndrome (Extracellular UPLC-MS assay)

Metabolic dysfunction is a primary feature of Werner syndrome (WS), a human premature aging disease caused by mutations in the gene encoding the Werner (WRN) DNA helicase. WS patients exhibit severe metabolic phenotypes, but the underlying mechanisms are not understood, and whether the metabolic ...

2019-10-17 | MTBLS1221 | MetaboLights

NAD+ augmentation restores mitophagy and limits accelerated aging in Werner syndrome (Intracellular UPLC-MS assay)

2019-10-17 | MTBLS1223 | MetaboLights

Genome-scale reconstruction of the sigma factor network in E. coli

We report the application of single-molecule-based sequencing technology for high-throughput profiling of transcription start sites for Escherichia coli under different conditions. By obtaining sequence from 5' RACE (rapid amplification of cDNA ends) followed by deep sequencing, we generated genome-...

ORGANISM(S): Escherichia coli str. K-12 substr. MG1655

2014-02-05 | E-GEOD-46737 | biostudies-arrayexpress

Genome-wide DNA methylation profiling of Progeria and Werner syndrome patients

DNA methylation gradiently changes with age and is likely to be involved in aging-related processes resulting in phenotype changes and increased susceptibility to certain diseases. The Hutchinson-Gilford Progeria Syndrome (HGP) and Werner Syndrome are two premature aging diseases showing features of...

ORGANISM(S): Homo sapiens

2013-01-14 | E-GEOD-42865 | biostudies-arrayexpress

Comparative analysis of regulatory elements between Escherichia coli and Klebsiella pneumoniae by genome-wide transcription start site profiling [TSS-Seq]

We report the application of single-molecule-based sequencing technology for high-throughput profiling of transcription start sites for two enterobacteria: Escherichia coli and Klebsiella pneumoniae.By obtaining over fourteen billion bases of sequence from 5' RACE (rapid amplification of cDNA ends) ...

ORGANISM(S): Escherichia coli K-12

2012-07-30 | E-GEOD-35821 | biostudies-arrayexpress

Listeria monocytogenes EGD and EGD-e

Transcriptional profile after growth in MM (minimal medium (Premaratne et al. 2001) supplemented with 50 mM Glucose. Note: strain "EGD" has not been deposited at ATCC/NCTC. It is a derivative of the original Murray strain (Murray et al. 1926), obtained from S.H.E. Kaufmann. Strain "E...

ORGANISM(S): Listeria monocytogenes

2008-11-30 | E-GEOD-12146 | biostudies-arrayexpress

Altered gene expression in Werner & Bloom syndromes is associated with sequences having G-quadruplex forming potential

The human Werner and Bloom syndromes (WS and BS) are caused by deficiencies in the WRN and BLM RecQ helicases, respectively. WRN, BLM and their S. cerevisiae homologue Sgs1, are particularly active in vitro in unwinding G-quadruplex DNA (G4-DNA), a family of non-canonical nucleic acid structures fo...

ORGANISM(S): Homo sapiens

2009-12-09 | E-GEOD-19205 | biostudies-arrayexpress

Crystal structure of diethyl (E)-2-[(benzo-furan-2-yl)methyl-idene]succinate.

Not available

S-EPMC4645082 | biostudies-literature

Identification and validation of antisense RNAs in Escherichia coli

In this study transcriptional start sites (TSS) of E. coli were determined for several growth conditions To detect the complement of transcripts expressed from E. coli, we collected two independent biological replicates (B1 and B2 samples) from MG1655 wild type strain grown to exponential (OD 600 ~0...

ORGANISM(S): Escherichia coli str. K-12 substr. MG1655

2014-10-18 | E-GEOD-55199 | biostudies-arrayexpress

Development of Zika Virus E Variants for Pseudotyping Retroviral Vectors Targeting Glioblastoma Cells.

Not available

S-EPMC10572498 | biostudies-literature

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