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MetabolomicsMolecular structural diversity of mitochondrial cardiolipins
Current strategies used to quantitatively describe the biological diversity of lipids by mass spectrometry are often limited in assessing the exact structural variability of individual molecular species in detail. A major challenge is represented by the extensive isobaric overlap present among lipid...
2021-01-11 | MTBLS636 | MetaboLights
MetabolomicsPhospholipid acyl chain diversity controls the tissue-specific assembly of mitochondrial cardiolipins

Cardiolipin (CL) is a phospholipid specific for mitochondrial membranes and crucial for many core tasks of this organelle. Its side chain configurations are tissue-specific, functionally important and generated via post-biosynthetic remodeling. However, this process lacks the necessary specificit...

2020-05-22 | MTBLS1446 | MetaboLights
UnknownTreatment Intensification in HIV-Infected Patients Is Associated With Reduced Frequencies of Regulatory T Cells.
Not available
S-EPMC5936794 | biostudies-literature
GenomicsEssential role of EBF1 in B cell immunity by controlling the generation and function of distinct mature B cell types
The transcription factor EBF1 is essential for lineage specification in early B cell development. Here we demonstrate by conditional mutagenesis that EBF1 was required for B cell commitment, pro-B cell development and subsequent transition to pre-B cells. Later in B cell development, EBF1 was essent...
ORGANISM(S): Mus musculus 
2012-03-20 | E-GEOD-35857 | biostudies-arrayexpress
TranscriptomicsStage-specific control of early B cell development by the transcription factor Ikaros
Ikaros is an essential regulator of lymphopoiesis. Here, we studied the B-cell-specific function of Ikaros by conditional Ikzf1 inactivation in pro-B cells. B-cell development was arrested at an aberrant ‘pro-B’ cell stage characterized by increased cell adhesion and loss of pre-B cell receptor sign...
ORGANISM(S): Mus musculus 
2014-02-09 | E-GEOD-53595 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Arabidopsis inflorescence stalks of intact plants after infection with A. tumefaciens
The intention of these gene expression analysis was to study host responses to an infection with Agrobacterium tumefaciens at different stages of crown gall development. Therefore the transcriptome of infected inflorescence stalk tissue and mature crown galls of Arabidopsis thaliana (WS-2) was deter...
ORGANISM(S): Arabidopsis thaliana 
2009-12-02 | E-GEOD-14106 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Arabidopsis thaliana mature crown galls
This study describes physiological changes, morphological adaptations and the regulation of pathogen defense responses in Arabidopsis crown galls. Crown gall development was induced on intact plants under most natural conditions with Agrobacterium tumefaciens. Differential gene expression and the me...
ORGANISM(S): Arabidopsis thaliana 
2009-12-02 | E-GEOD-13927 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of Arabidopsis after infection with different strains of Agrobacterium tumefaciens
This study focuses on responses of the host plant to infection with Agrobacterium tumefaciens. Genome wide changes in gene expression were integrated with the alterations in metabolite levels three hours after inoculation of agrobacteria. Plants were infected with the virulent strain C58, harboring ...
ORGANISM(S): Arabidopsis thaliana 
2009-12-02 | E-GEOD-13929 | biostudies-arrayexpress
TranscriptomicsRNA sequencing of HEK293T cells expressing peptide 9J10, a 14-3-3 interacting peptide
We investigated the transcriptome profile of HEK293T cells transfected with a plasmid encoding 9J10, a peptide isolated in a phenotypic screen from a library of peptides derived from bacterial and archaeal genomes. The peptide was identified in a screen for FOXO3a reactivation and has been shown to...
ORGANISM(S): Homo sapiens 
2021-05-28 | E-MTAB-10161 | biostudies-arrayexpress
ProteomicsExercise forms a metabolic-shield in distant organs blocking cancer progression and metastatic dissemination-Part 2
Exercise prevents cancer incidence and recurrence, yet the underlying mechanism remains mostly unknown. Here we report that exercise induces a metabolic reprogramming of internal organs, increasing their nutrient demand, thus protecting them against metastatic colonization by limiting nutrient avail...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD035648 | Pride
Metabolism Cancer Exercise 
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