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ProteomicsVitamin C alters the amount of specific endoplasmic reticulum associated proteins involved in lipid metabolism in the liver of mice synthesizing a nonfunctional WRN mutant protein
Werner syndrome (WS) is a premature aging disorder caused by mutations in a DNA helicase/exonuclease. Mice lacking the helicase domain of the Wrn protein orthologue exhibit transcriptomic and metabolic alterations, some of which are reversed by vitamin C. Recent studies on the liver of these animals...
ORGANISM(S): Mus musculus (Mouse) 
2018-03-02 | PXD007758 | Pride
Mouse model Liver proteome Lc-msms shotgun Vitamin c Endoplasmic reticulum Werner syndrome Label free quantification 
ProteomicsIntegrated liver and serum proteomics reveal sexual dimorphism and alteration of several immune response proteins in an aging Werner syndrome mouse model
Werner syndrome is a progeroid disorder caused by mutations in a protein (Wrn) containing both a DNA exonuclease and DNA helicase domain. In this study, we identified proteins that exhibit abundance differences in the serum and liver tissue of wild type and Wrn mutant mice at four and ten months of ...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2023-04-04 | MSV000091632 | MassIVE
GenomicsGenomic binding of Pol III transcription machinery and relationship with TFIIS distribution in mouse embryonic stem cells
RNA polymerase (RNA Pol) III synthesizes the tRNAs, the 5S ribosomal RNA and a small number of untranslated RNAs. In vitro, it also transcribes short interspersed nuclear elements (SINEs). We investigated the distribution of RNA Pol III and its associated transcription factors on the genome of mouse...
ORGANISM(S): Mus musculus 
2011-09-16 | E-MTAB-767 | biostudies-arrayexpress
GenomicsFunctional link between Rad2 and Mediator
In this study, we generate genomic maps of Mediator, Rad2, Pol II, TBP and TFIIH, by ChIP coupled to next generation sequencing technology (ChIP-seq), in wild type strains from Saccharomyces cerevisiae. A related study involving ChIP-chip analysis of Rad2 occupany is also deposited at ArrayExpress ...
ORGANISM(S): Saccharomyces cerevisiae 
2013-12-01 | E-MTAB-1595 | biostudies-arrayexpress
TranscriptomicsGenome-wide binding of Fhl1 and Ifh1 +/- Rapamycin
Array design -Platform: amino-silane coated glass slides (GAPS II, Corning) -S. cerevisiae intergenic regions amplified from S288C genomic DNA (ResGen) using the intergenic region primer oligonucleotides (ResGen) (Harismendy et al. EMBO J. 22(18): 4738-4747, 2003). The primers allow the amplificati...
ORGANISM(S): Saccharomyces cerevisiae 
2010-06-05 | E-GEOD-1944 | biostudies-arrayexpress
GenomicsFunctional link between TFIIB and Mediator
In this study, we generate genomic maps of Mediator, Pol II, TBP, TFIIH, TFIIA, TFIIB, TFIIE, TFIIF, by ChIP coupled to next generation sequencing technology (ChIP-seq), in wild type strains from Saccharomyces cerevisiae and in a mutant for the Mediator essential subunit Med10
ORGANISM(S): Saccharomyces cerevisiae 
2017-01-24 | E-MTAB-4607 | biostudies-arrayexpress
UnknownNot All Injuries Are the Same: Different Patterns in Sports Injuries and Their Psychosocial Correlates.
Not available
S-EPMC10747018 | biostudies-literature
UnknownEffect of a mesitylene-based ligand cap on the relaxometric properties of Gd(III) hydroxypyridonate MRI contrast agents.
Not available
S-EPMC3732192 | biostudies-literature
UnknownA Single-Pot Template Reaction Towards a Manganese-Based T1 Contrast Agent.
Not available
S-EPMC10947048 | biostudies-literature
UnknownA Single-Pot Template Reaction Towards a Manganese-Based T<sub>1</sub> Contrast Agent.
Not available
S-EPMC8252504 | biostudies-literature
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