A Single-Pot Template Reaction Towards a Manganese-Based T₁ Contrast Agent.

ABSTRACT: Manganese-based contrast agents (MnCAs) have emerged as suitable alternatives to gadolinium-based contrast agents (GdCAs). However, due to their kinetic lability and laborious synthetic procedures, only a few MnCAs have found clinical MRI application. In this work, we have employed a highly innovative single-pot template synthetic strategy to develop a MnCA, MnL^Me, and studied the most important physicochemical properties in vitro. MnL^Me displays optimized r ₁ relaxivities at both medium (20 and 64 MHz) and high magnetic fields (300 and 400 MHz) and an enhanced r ₁ ^b=21.1 mM^-1 s^-1 (20 MHz, 298 K, pH 7.4) upon binding to BSA (K _a=4.2×10³ M^-1). In v

SUBMITTER: Anbu S 

PROVIDER: S-EPMC10947048 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature