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MetabolomicsTissue metabolites in diffuse glioma and their modulations by IDH1 mutation, histology, and treatment
The discovery of the oncometabolite 2-hydroxyglutarate in isocitrate dehydrogenase 1-mutated (IDH1-mutated) tumor entities affirmed the role of metabolism in cancer. However, large databases with tissue metabolites that are modulated by IDH1 mutation remain an area of development. Here, we present a...
2022-09-07 | MTBLS3873 | MetaboLights
TranscriptomicsFunctional analysis of the cytoprotective transcription factor Nrf2 in skin morphogenesis and disease: Identification of Nrf2 target genes
The Nrf2 transcription factor is a key player in the cellular stress response, which regulates the expression of important antioxidant enzymes and other cytoprotective proteins. We recently generated a novel transgenic mouse model to determine the function of Nrf2 in the skin. These mice revealed in...
ORGANISM(S): Mus musculus 
2012-02-01 | E-GEOD-35160 | biostudies-arrayexpress
ProteomicsRetinoic acid-induced 2 protein contributes to proficient homologous recombination and maintains genomic stability in breast cancer
Genome instability is a fundamental feature and hallmark of cancer associated with aggressiveness, drug resistance and poor prognosis. Here, we provide evidence for an essential function of the Retinoic acid-induced 2 (RAI2) protein as a suppressor of genome instability. Analysis of clinical samples...
ORGANISM(S): Homo sapiens (Human) 
2025-08-04 | PXD047189 | Pride
Genomic instability Premature mitotic entry Breast cancer Homologous recombination Poly-(adp-ribose) 
TranscriptomicsRAI2 overexpression in MDA-MB231
MDA-MB231 cells were transfected with control vector, RAI2-overexpression vector, or vector with RAI2-4A, which has a mutated interaction domain w.r.t. CtBP/CtBP2 Three replicates each of control condition, RAI2 overexpression or RAI2-4A overexpression.
ORGANISM(S): Homo sapiens 
2015-06-15 | E-GEOD-65489 | biostudies-arrayexpress
TranscriptomicsDual Roles of the Transcription Factor Grainyhead-like 2 (GRHL2) in Breast Cancer
Using a retrovirus-mediated cDNA expression cloning approach we identified the grainyhead-like 2 (GRHL2) transcription factor as novel protooncogene. Overexpression of GRHL2 in NIH3T3 cells induced striking morphological changes, an increase in cell proliferation, anchorage-independent growth, and t...
ORGANISM(S): Mus musculus 
2013-09-05 | E-GEOD-43610 | biostudies-arrayexpress
UnknownVariation in Risk-Standardized Acute Admission Rates Among Patients With Heart Failure in Accountable Care Organizations: Implications for Quality Measurement.
Not available
S-EPMC10356066 | biostudies-literature
TranscriptomicsTranscription profiling of mice heart tissue treated with tetrahydrobiopterin compounds
Tetrahydrobiopterin compounds prolong allograft survival independent of their effect on nitric oxide synthase activity
ORGANISM(S): Mus musculus 
2007-12-04 | E-GEOD-1809 | biostudies-arrayexpress
TranscriptomicsGene expression in human KPL-1 breast cancer cells under RAI2 knock-down
Gene expression was measured in human KPL-1 breast cancer cell lines, both with and without knock-down of RAI2 by shRNA. Measurements of each condition were done in triplicates.
ORGANISM(S): Homo sapiens 
2021-01-31 | E-MTAB-7071 | biostudies-arrayexpress
GenomicsMelanoma - Exome sequencing
Direct identification of clinically relevant neoepitopes presented on native human melanoma tissue by mass spectrometry - Exome sequencing
PRJEB15496 | ENA
ProteomicsDirect identification of clinically relevant neoepitopes presented on native human melanoma tissue by mass spectrometry
Although mutations may represent attractive targets for immunotherapy, direct identification of mutated peptide ligands isolated from human leukocyte antigens (HLA) on the surface of native tumor tissue has so far not been successful. Using advanced mass spectrometry (MS) analysis, we survey the mel...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-01-30 | MSV000080517 | MassIVE
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