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MetabolomicsPREDICT: untargeted metabolomic profiling in a Brassica napus (canola) breeding population by GC-MS

Genome-wide association studies (GWAS) identified thousands of genetic loci associated with complex plant traits, including many traits of agronomical importance. However, functional interpretation of GWAS results remains challenging because of large candidate regions due to linkage disequilibriu...

2023-11-20 | MTBLS8056 | MetaboLights
TranscriptomicsReduced Treg suppressive function and HIF-1α expression in hypoxia
Recently, hypoxia via the transcription factor HIF-1a has been implicated to play an important role for the fate of the adaptive immune response by regulatory T cells (Treg) and T helper 17 cells (TH17) in the mouse model. However, the reports on the effect of HIF-1a are conflicting and so far no fu...
ORGANISM(S): Homo sapiens 
2013-12-31 | E-GEOD-41999 | biostudies-arrayexpress
ProteomicsSgt1 interactome analysis under proteostatic stress and steady state conditions
Buildup of misfolded proteins are prevented by chaperone-assisted refolding and/or proteasome dependent degradation. The coordination of these two protein quality control (PQC) systems is not fully understood. We identified the essential Hsp90 co-chaperone Sgt1 as a new member of a general PQC linki...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2021-07-02 | PXD016174 | Pride
Heat shock Sgt1 Hapi Saccharomyces cerevisiae Protein quality control 
ProteomicsDirect identification of clinically relevant neoepitopes presented on native human melanoma tissue by mass spectrometry
Although mutations may represent attractive targets for immunotherapy, direct identification of mutated peptide ligands isolated from human leukocyte antigens (HLA) on the surface of native tumor tissue has so far not been successful. Using advanced mass spectrometry (MS) analysis, we survey the mel...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-01-30 | MSV000080517 | MassIVE
TranscriptomicsCircadian Clock Activity in Mouse and Human CD4+ T Cells
Though it is well established that immunological functions of CD4+ T cells are time of day-dependent, the underlying molecular mechanisms remain largely obscure. To address the question whether T cells themselves harbor a functional clock driving circadian rhythms of immune function, we analyzed clo...
ORGANISM(S): Homo sapiens 
2012-04-30 | E-GEOD-29583 | biostudies-arrayexpress
UnknownOccupational exposure to hepatitis C virus: early T-cell responses in the absence of seroconversion in a longitudinal cohort study.
Not available
S-EPMC3749009 | biostudies-literature
MetabolomicsThe HuMet Repository: Watching human metabolism at work
Metabolism oscillates between catabolic and anabolic states depending on food intake, exercise, or stresses that change a multitude of metabolic pathways simultaneously. We present the HuMet Repository for exploring dynamic metabolic responses to oral glucose/lipid loads, mixed meals, 36-h fasting, ...
2024-07-23 | MTBLS89 | MetaboLights
TranscriptomicsPrimary transcriptome map of the hyperthermophilic archaeon ThermococcusM-BM- kodakarensis
Background: Prokaryotes have relatively small genomes, densely-packed and apparently dominated by protein-encoding sequences. However, data now generated by high throughput RNA sequencing (RNA-seq) reveal surprisingly more-complex transcriptomes with many previously unrecognized and unanticipated ...
ORGANISM(S): Thermococcus kodakarensis KOD1 
2014-08-18 | E-GEOD-56262 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Arabidopsis inflorescence stalks of intact plants after infection with A. tumefaciens
The intention of these gene expression analysis was to study host responses to an infection with Agrobacterium tumefaciens at different stages of crown gall development. Therefore the transcriptome of infected inflorescence stalk tissue and mature crown galls of Arabidopsis thaliana (WS-2) was deter...
ORGANISM(S): Arabidopsis thaliana 
2009-12-02 | E-GEOD-14106 | biostudies-arrayexpress
GenomicsFunctional link between TFIIB and Mediator
In this study, we generate genomic maps of Mediator, Pol II, TBP, TFIIH, TFIIA, TFIIB, TFIIE, TFIIF, by ChIP coupled to next generation sequencing technology (ChIP-seq), in wild type strains from Saccharomyces cerevisiae and in a mutant for the Mediator essential subunit Med10
ORGANISM(S): Saccharomyces cerevisiae 
2017-01-24 | E-MTAB-4607 | biostudies-arrayexpress
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