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TranscriptomicsDissection of the heat-shock response in Mycobacterium tuberculosis using mutants and microarrays
Regulation of the expression of heat-shock proteins plays an important role in the pathogenesis of Mycobacterium tuberculosis. The heat-shock response of bacteria involves genome-wide changes in gene expression. A combination of targeted mutagenesis and whole-genome expression profiling was used to ...
ORGANISM(S): Mycobacterium tuberculosis 
2007-03-07 | E-BUGS-2 | biostudies-arrayexpress
TranscriptomicsNon-Replicating Mycobacterium tuberculosis Elicits a Reduced Infectivity Profile with Corresponding Modifications to the Cell Wall and Extracellular Matrix
A key feature of Mycobacterium tuberculosis is its ability to become dormant in the host. Little is known of the mechanisms by which these bacilli are able to persist in this state. Therefore, the focus of this study was to emulate environmental conditions encountered by M. tuberculosis in the granu...
ORGANISM(S): Mycobacterium tuberculosis 
2016-11-14 | E-BUGS-142 | biostudies-arrayexpress
TranscriptomicsGenome-scale analysis in blood progenitor and mast cells reveals how lineage-affiliated transcription factors control distinct regulatory programs [ChIP-Seq/RNA-Seq Experiments]
Despite major advances in the generation of genome-wide binding maps, the mechanisms by which transcription factors (TFs) regulate cell type identity have remained largely obscure. Through comparative analysis of 10 key haematopoietic TFs in both mast cells and blood progenitors, we demonstrate that...
ORGANISM(S): Mus musculus 
2014-04-24 | E-GEOD-48085 | biostudies-arrayexpress
TranscriptomicsGenome-scale analysis in blood progenitor and mast cells reveals how lineage-affiliated transcription factors control distinct regulatory programs [Beadchip Experiments]
Despite major advances in the generation of genome-wide binding maps, the mechanisms by which transcription factors (TFs) regulate cell type identity have remained largely obscure. Through comparative analysis of 10 key haematopoietic TFs in both mast cells and blood progenitors, we demonstrate that...
ORGANISM(S): Mus musculus 
2014-04-24 | E-GEOD-47988 | biostudies-arrayexpress
TranscriptomicsGenome-scale analysis in blood progenitor and mast cells reveals how lineage-affiliated transcription factors control distinct regulatory programs [Beadchip Experiments #2]
Despite major advances in the generation of genome-wide binding maps, the mechanisms by which transcription factors (TFs) regulate cell type identity have remained largely obscure. Through comparative analysis of 10 key haematopoietic TFs in both mast cells and blood progenitors, we demonstrate that...
ORGANISM(S): Mus musculus 
2014-04-24 | E-GEOD-55244 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of differentiated human blood cells: The HaemAtlas
Transcription profiling of highly purified blood cells from normal individuals
ORGANISM(S): Homo sapiens 
2009-02-06 | E-TABM-633 | biostudies-arrayexpress
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