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MetabolomicsSubcellular antibiotic visualization reveals a dynamic drug reservoir in infected macrophages
Tuberculosis, caused by the intracellular pathogen Mycobacterium tuberculosis, remains the world's deadliest infectious disease. Sterilizing chemotherapy requires at least 6 months of multidrug therapy. Difficulty visualizing the subcellular localization of antibiotics in infected host cells means t...
2020-12-07 | MTBLS959 | MetaboLights
MetabolomicsCyclooxygenase-2, Asymmetric Dimethylarginine, and the Cardiovascular Hazard From Nonsteroidal Anti-Inflammatory Drugs (Murine kidney and plasma UPLC-MS/MS assay)

BACKGROUND: Large-scale, placebo-controlled trials established that nonsteroidal anti-inflammatory drugs confer a cardiovascular hazard: this has been attributed to depression of cardioprotective products of cyclooxygenase (COX)-2, especially prostacyclin. An alternative mechanis...

2019-08-22 | MTBLS680 | MetaboLights
TranscriptomicsTranscription profiling by array of human BMPR2 mutation carriers with and without evidence of pulmonary arterial hypertension
Background: While BMPR2 mutation strongly predisposes to pulmonary arterial hypertension (PAH), only 20% of mutation carriers develop clinical disease. This finding suggests that modifier genes contribute to FPAH clinical expression. Since modifiers are likely to be common alleles, this problem is n...
ORGANISM(S): Homo sapiens 
2008-10-25 | E-GEOD-10767 | biostudies-arrayexpress
ProteomicsProteomic analysis of urinary microvesicles reveal biomarkers for neurologic disease
Background- Extracellular vesicles (EVs) harbor thousands of proteins that hold promise for biomarker development. Usually difficult to purify, EVs in urine are relatively easily obtained and have demonstrated efficacy for kidney disease prediction. Herein, we further characterize the proteome of ur...
ORGANISM(S): Homo sapiens (Human) 
2019-11-12 | PXD013710 | Pride
Biomarkers  neurodegeneration  exosomes  parkinson's disease  alzheimer's disease 
ProteomicsProteomic analysis of urinary microvesicles - logitudinal Study
This is a small pilot study for two voluteers with average diets that gave morning urine specimens across six samplings over 10-11 days to determine the day to day stability of extracellular vesical proteomes.
ORGANISM(S): Homo sapiens (Human) 
2019-11-11 | PXD013700 | Pride
Proteomics Extracellular vesicals Urine Logitudinal 
MetabolomicsComprehensive Metabolic Profiling of Age-Related Mitochondrial Dysfunction in the High-Fat-Fed ob/ob Mouse Heart
The ectopic deposition of fat is thought to lead to lipotoxicity and has been associated with mitochondrial dysfunction and diabetic cardiomyopathy. We have measured mitochondrial respiratory capacities in the hearts of ob/ob and wild-type mice on either a regular chow (RCD) or high-fat (HFD) diet a...
2015-11-17 | MTBLS173 | MetaboLights
TranscriptomicsBmpr2 mutation in murine PMVEC
Pulmonary arterial hypertension (PAH) is thought to be driven by dysfunction of pulmonary vascular microendothelial cells (PMVEC). Most hereditary PAH is associated with BMPR2 mutations. However, the physiologic and molecular consequences of expression of BMPR2 mutations in PMVEC are unknown. PMVEC ...
ORGANISM(S): Mus musculus 
2011-07-01 | E-GEOD-28043 | biostudies-arrayexpress
UnknownSerious Falls in Middle-Aged Veterans: Development and Validation of a Predictive Risk Model.
Not available
S-EPMC7744431 | biostudies-literature
UnknownImmunologic response in treatment-naive HIV-2-infected patients: the IeDEA West Africa cohort.
Not available
S-EPMC4748109 | biostudies-literature
UnknownImmunodominance of antigenic site B over site A of hemagglutinin of recent H3N2 influenza viruses.
Not available
S-EPMC3405050 | biostudies-literature
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