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UnknownExposure Patterns Driving Ebola Transmission in West Africa: A Retrospective Observational Study.

Background

The ongoing West African Ebola epidemic began in December 2013 in Guinea, probably from a single zoonotic introduction. As a result of ineffective initial control efforts, an Ebola outbreak of unprecedented scale emerged. As of 4 May 2015, it had resulted in more than 19,000 proba...
S-EPMC5112802 | biostudies-literature
MetabolomicsMetabolic profiling of rheumatoid arthritis neutrophils reveals altered energy metabolism that is not affected by JAK inhibition
Neutrophils play a key role in the pathophysiology of rheumatoid arthritis (RA) where release of ROS and proteases directly causes damage to joints and tissues. Neutrophil function is directly affected by Janus Kinase (JAK) inhibitor drugs, including tofacitinib and baricitinib, which are clinically...
2023-07-11 | MTBLS4766 | MetaboLights
UnknownA prospective international multisite randomized controlled trial of water exchange with and without distal cap(s) in adenoma detection.

Background

Interval cancers are linked to a low adenoma detection rate (ADR), prompting calls for benchmark-guided ADR performance improvement. Although water exchange and a straight cap (CAP) have been reported to independently improve ADR, the effects of Daisycuff™ and Endocuff ...
S-EPMC12850690 | biostudies-literature
UnknownExtracellular Matrix Rigidity Modulates Human Cervical Smooth Muscle Contractility-New Insights into Premature Cervical Failure and Spontaneous Preterm Birth.
Spontaneous preterm birth (sPTB), a major cause of infant morbidity and mortality, must involve premature cervical softening/dilation for a preterm vaginal delivery to occur. Yet, the mechanism behind premature cervical softening/dilation in humans remains unclear. We previously reported the non-pre...
S-EPMC9344974 | biostudies-literature
UnknownRisk Factors for Cardiac and Non-cardiac Causes of Death in Males with Duchenne Muscular Dystrophy.
As survival and neuromuscular function in Duchenne muscular dystrophy (DMD) have improved with glucocorticoid (GC) therapy and ventilatory support, cardiac deaths are increasing. Little is known about risk factors for cardiac and non-cardiac causes of death in DMD. A multi-center retrospective cohor...
S-EPMC7328368 | biostudies-literature
UnknownIdentifying Factors Associated With HIV Viral Suppression and Health Care Outcomes in the Florida Cohort Study Wave 3: Protocol for a Prospective Cohort Study.

Background

Ending the HIV epidemic remains a high public health priority, and the state of Florida continues to have high HIV prevalence and incidence.

Objective

This protocol aims to identify factors associated with the HIV care continuum and HIV-related comorbidities, with a focus o...
S-EPMC12511819 | biostudies-literature
UnknownUse of advanced heart failure therapies in Duchenne muscular dystrophy.

Background

As survival and neuromuscular function in Duchenne Muscular Dystrophy (DMD) improve with glucocorticoid therapy and respiratory advances, the proportion of cardiac deaths is increasing. Little is known about the use and outcomes of advanced heart failure (HF) therapies in this pop...
S-EPMC6663084 | biostudies-literature
UnknownPredisposition to hematopoietic malignancies by deleterious germline CHEK2 variants.
The role of germline CHEK2 variants in hematopoietic malignancies (HMs) is poorly understood. We examined pathogenic/likely pathogenic (P/LP) CHEK2 variants in patients with hereditary HMs (HHMs), a solid tumor risk cohort, public datasets, and a knock-in mouse model. In the HHM cohort, 57 probands ...
S-EPMC12208901 | biostudies-literature
UnknownAmilorides inhibit SARS-CoV-2 replication in vitro by targeting RNA structures.
The SARS-CoV-2 pandemic, and the likelihood of future coronavirus pandemics, emphasized the urgent need for development of novel antivirals. Small-molecule chemical probes offer both to reveal aspects of virus replication and to serve as leads for antiviral therapeutic development. Here, we report o...
S-EPMC8626076 | biostudies-literature
TranscriptomicsExpression data from fetal mouse lung from mothers fed high fibre or acetate
We used microarrays to detail the global programme of gene expression in the fetal lung late in gestation, from mothers that had been fed normal chow, high fibre, or acetate in the drinking water. The experiment was designed to examine the hypothesis that metabolites of the mother i.e. acetate could...
ORGANISM(S): Mus musculus 
2015-06-29 | E-GEOD-69525 | biostudies-arrayexpress
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