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UnknownCrystal structures of the SAM-III/S(MK) riboswitch reveal the SAM-dependent translation inhibition mechanism.
Not available
S-EPMC3467307 | biostudies-literature
TranscriptomicsIdentification of genes critical for resistance to infection by West Nile virus using RNA-Seq analysis
Background: West Nile virus is an emerging infection of biodefense concern and there are no available treatments or vaccines. Here we used a high-throughput method based on a novel gene expression analysis, RNA-Seq, to give a global picture of differential gene expression by primary human macrophage...
ORGANISM(S): Homo sapiens 
2014-01-08 | E-GEOD-40718 | biostudies-arrayexpress
UnknownStructural and functional basis of low-affinity SAM/SAH-binding in the conserved MTase of the multi-segmented Alongshan virus distantly related to canonical unsegmented flaviviruses.
Not available
S-EPMC10575543 | biostudies-literature
UnknownDiversity of the reaction mechanisms of SAM-dependent enzymes.
Not available
S-EPMC7982431 | biostudies-literature
TranscriptomicsTranscriptional profile of mice with good and poor spatial learning during West Nile virus recovery
Greater than 50% of patients who survive neuroinvasive West Nile virus (WNV), a mosquito-borne, positive-sense strand flavivirus, exhibit cognitive sequelae including memory impairments which may last several years. High survival rates from WNV neuroinvasive disease (WNND) (>90%) have led to hundred...
ORGANISM(S): Mus musculus 
2016-06-27 | E-GEOD-72139 | biostudies-arrayexpress
UnknownDeciphering the regulatory and catalytic mechanisms of an unusual SAM-dependent enzyme.
Not available
S-EPMC6533283 | biostudies-literature
MetabolomicsComparative Metabolomic Sampling of Upper and Lower Airways by Four Different Methods to Identify Biochemicals That May Support Bacterial Growth
Bacteria need nutrients from the host environment to survive, yet we know little about which biochemicals are present in the airways (the metabolome), which of these biochemicals are essential for bacterial growth and how they change with airway disease. The aims of this pilot study were to develop ...
2019-06-13 | MTBLS179 | MetaboLights
UnknownComparative Analysis of Two NNMT Bisubstrate Inhibitors through Chemoproteomic Studies: Uncovering the Role of Unconventional SAM Analogue Moiety for Improved Selectivity.
Not available
S-EPMC11955877 | biostudies-literature
UnknownExploring Unconventional SAM Analogues To Build Cell-Potent Bisubstrate Inhibitors for Nicotinamide N-Methyltransferase.
Not available
S-EPMC8983580 | biostudies-literature
UnknownWest Nile virus methyltransferase catalyzes two methylations of the viral RNA cap through a substrate-repositioning mechanism.
Not available
S-EPMC2293060 | biostudies-literature
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