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TranscriptomicsA crucial role of the ubiquitously expressed transcription factor Sp1 at early stages of hematopoietic specification [array]
Mammalian development is regulated by the interplay of tissue-specific and ubiquitously expressed transcription factors, such as Sp1. Sp1 knock-out mice die in utero with multiple phenotypic aberrations, but the underlying molecular mechanism of this differentiation failure has been elusive. Here we...
ORGANISM(S): Mus musculus 
2014-06-12 | E-GEOD-52497 | biostudies-arrayexpress
UnknownExcised DNA circles from V(D)J recombination promote relapsed leukaemia.
Not available
S-EPMC12443594 | biostudies-literature
UnknownCut-and-Run: A Distinct Mechanism by which V(D)J Recombination Causes Genome Instability.
Not available
S-EPMC6509286 | biostudies-literature
GenomicsA crucial role of the ubiquitously expressed transcription factor Sp1 at early stages of hematopoietic specification [ChIP-Seq]
Mammalian development is regulated by the interplay of tissue-specific and ubiquitously expressed transcription factors, such as Sp1. Sp1 knock-out mice die in utero with multiple phenotypic aberrations, but the underlying molecular mechanism of this differentiation failure has been elusive. Here we...
ORGANISM(S): Mus musculus 
2014-06-12 | E-GEOD-52496 | biostudies-arrayexpress
GenomicsRUNX1 reshapes the epigenetic landscape at the onset of hematopoiesis
Cell fate decisions during hematopoiesis are governed by lineage-specific transcription factors, such as RUNX1, SCL/TAL1, FLI1 and C/EBP family members. In order to gain insight about how these transcription factors regulate the activation of hematopoietic genes during embryonic development, we meas...
ORGANISM(S): Mus musculus 
2012-10-18 | E-GEOD-40235 | biostudies-arrayexpress
TranscriptomicsRUNX1 reshapes the epigenetic landscape at the onset of hematopoiesis
Cell fate decisions during hematopoiesis are governed by lineage-specific transcription factors, such as RUNX1, SCL/TAL1, FLI1 and C/EBP family members. In order to gain insight about how these transcription factors regulate the activation of hematopoietic genes during embryonic development, we meas...
ORGANISM(S): Mus musculus 
2013-02-11 | E-GEOD-39662 | biostudies-arrayexpress
GenomicsA crucial role of the ubiquitously expressed transcription factor Sp1 at early stages of hematopoietic specification
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Mus musculus 
2014-06-12 | E-GEOD-52499 | biostudies-arrayexpress
UnknownTransferring genomics to the clinic: distinguishing Burkitt and diffuse large B cell lymphomas.
Not available
S-EPMC4512160 | biostudies-literature
TranscriptomicsNetwork analysis identifies proinflammatory plasma cell polarization for secretion of ISG15 in human autoimmunity
Plasma cells (PCs) as effectors of humoral immunity produce immunoglobulins to match pathogenic insult. However, emerging data suggests more diverse roles for PCs as regulators of immune and inflammatory responses via secretion of factors other than immunoglobulins. The extent to which such response...
ORGANISM(S): Homo sapiens 
2016-07-22 | E-GEOD-75007 | biostudies-arrayexpress
TranscriptomicsDepletion of RUNX1/ETO in t(8;21) AML cells leads to genome-wide changes in chromatin structure and transcription factor binding [expression array data]
The t(8;21) translocation fuses the DNA binding domain of the hematopoietic master regulator RUNX1 to the ETO protein. The resultant RUNX1/ETO fusion protein is a leukemia-initiating transcription factor that interferes with RUNX1 function. The result of this interference is a block in differentiati...
ORGANISM(S): Homo sapiens 
2012-03-27 | E-GEOD-29223 | biostudies-arrayexpress
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