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TranscriptomicsTranscriptomic profile of human preadipocyte treated by macrophages from adipose tissue
Obesity is characterized by a chronic auto-inflammation of the hypertrophied white adipose tissue (WAT) associated with metabolic and vascular complications. WAT of obese subjects produces inflammatory factors like cytokines (IL6, TNF-alpha) and chemokines (CCL2 and IL-8) originating mainly from the...
ORGANISM(S): Homo sapiens 
2013-03-22 | E-GEOD-28445 | biostudies-arrayexpress
ProteomicsTargeted MS assay to evaluate Cereblon neosubstrate changes in rabbit embryos following maternal administration of IMiDs
Targeted protein degradation is the selective removal of a protein of interest through hijacking intracellular protein cleanup machinery. This rapidly growing field currently relies heavily on the use of the E3 ligase Cereblon (CRBN) to target proteins for degradation, including the immunomodulatory...
ORGANISM(S): Oryctolagus Cuniculus 
2024-07-02 | PXD050568 | panorama
TranscriptomicsTranscriptomic profiling of peripheral blood mononuclear cells from patients with ParkinsonM-bM-^@M-^Ys disease and control subjects.
To get insight into systemic molecular events associated with ParkinsonM-bM-^@M-^Ys disease (PD), an age-related neurodegenerative disorder, we compared gene expression patterns of peripheral blood mononuclear cells (PBMC) derived from elderly healthy controls and from PD patients. Transcriptomic pr...
ORGANISM(S): Homo sapiens 
2012-03-20 | E-GEOD-22491 | biostudies-arrayexpress
TranscriptomicsDietary flavanols modulate the transcription of genes involved in cardiovascular pathology with complex changes of their DNA methylation state
Background: In a recent intervention study, the daily supplementation with 200 mg monomeric and oligomeric flavanols (MOF) from grape seeds for 8 weeks revealed a vascular health benefit in male smokers. The objective of the present study was to determine the impact of MOF consumption on the gene ex...
ORGANISM(S): Homo sapiens 
2014-07-30 | E-GEOD-54643 | biostudies-arrayexpress
UnknownIn Vivo Evidence of Reduced Integrity of the Gray-White Matter Boundary in Autism Spectrum Disorder.
Not available
S-EPMC6093436 | biostudies-literature
TranscriptomicsImpact of monomeric and oligomeric flavanols (MOF) consumption on the gene expression profile of leukocytes (human)
Background: In a recent intervention study, the daily supplementation with 200mg monomeric and oligomeric flavanols (MOF) from grape seeds for 8 weeks revealed a vascular health benefit in male smokers. The objective of the present study was to determine the impact of MOF consumption on the gene exp...
ORGANISM(S): Homo sapiens 
2014-07-30 | E-GEOD-54325 | biostudies-arrayexpress
MetabolomicsLongitudinal multi-omics reveals subset-specific mechanisms underlying irritable bowel syndrome

The gut microbiome has been implicated in multiple human chronic gastrointestinal (GI) disorders. Determining its mechanistic role in disease has been difficult due to apparent disconnects between animal and human studies and lack of an integrated multi-omics view of disease-specific physiologica...

2020-09-08 | MTBLS1396 | MetaboLights
ProteomicsTime series and steady state proteomics of Pseudomonas aeruginosa phenazine mutants
Microbes in biofilms face the challenge of substrate limitation. In particular, cells in Pseudomonas aeruginosa biofilms growing in the laboratory or during host colonization often become limited for oxygen. Previously we found that phenazines, antibiotics produced by P. aeruginosa, balance the intr...
ORGANISM(S): Pseudomonas aeruginosa PA14-RN6 
2018-10-19 | PXD008924 | Pride
Biofilm  phenazines  denitrification  pseudomonas aeruginosa 
MetabolomicsMetabolomic profiling of Fraxinus excelsior genotypes tolerant or susceptible to ash dieback disease reveals changes in iridoid glycosides
European common ash, Fraxinus excelsior L., is currently threatened by Ash dieback (ADB) caused by the fungus, Hymenoscyphus fraxineus. To detect and identify metabolites that may be products of pathways important in contributing to resistance against H. fraxineus we performed untargeted metabolomic...
2016-11-09 | MTBLS372 | MetaboLights
TranscriptomicsTranscription profiling of Arabidopsis leaves, roots and whole plants grown in high or low phosphate conditions for different lengths of time
The effects of phosphate starvation in Arabidopsis thaliana (L.) plants were compared in plants grown in liquid MS medium transferred in low or high Pi and in plants grown vertically in petri dishes during 10 days. In the transfer experiments, 2 treatments were analysed for evaluating the short-(3, ...
ORGANISM(S): Arabidopsis thaliana 
2006-09-01 | E-MEXP-791 | biostudies-arrayexpress
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