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GenomicsVitamin C induces Tet-dependent DNA demethylation in ES cells to promote a blastocyst-like methylome [MeDIP-Seq]
DNA methylation is a heritable epigenetic modification involved in gene silencing, imprinting, and the suppression of retrotransposons. Global DNA demethylation occurs in the early embryo and the germline and may be mediated by Tet (ten-eleven-translocation) enzymes, which convert 5-methylcytosine (...
ORGANISM(S): Mus musculus 
2013-06-30 | E-GEOD-46402 | biostudies-arrayexpress
TranscriptomicsVitamin C induces Tet-dependent DNA demethylation in ES cells to promote a blastocyst-like methylome [Affymetrix]
DNA methylation is a heritable epigenetic modification involved in gene silencing, imprinting, and the suppression of retrotransposons. Global DNA demethylation occurs in the early embryo and the germline and may be mediated by Tet (ten-eleven-translocation) enzymes, which convert 5-methylcytosine (...
ORGANISM(S): Mus musculus 
2013-06-30 | E-GEOD-46319 | biostudies-arrayexpress
TranscriptomicsSeeds of Pisum sativum L. cv Alaska Early: non-aged controls vs. Aged
Seeds of Pisum sativum L. cv Alaska Early (purchased from the ‘Abundant Life Seed Foundation’, Port Townsend, USA) were equilibrated for approximately 5 weeks in tightly sealed boxes over 300 g-1 non-saturated LiCl (Hay et al. 2008), producing 60% relative humidity, in a temperature-controlled r...
ORGANISM(S): Pisum sativum 
2010-10-22 | E-GEOD-24864 | biostudies-arrayexpress
TranscriptomicsOpen Ocean and Coastal Strains of Marine Synechococcus display distinctly different Global Responses to DNA Damaging Agents
We have looked at the transcriptional response of well characterised Synechococcus open ocean (WH8102) and coastal (CC9311) isolates to two DNA damaging agents, mitomycin C and ethidium bromide, using whole genome expression microarrays. The coastal strain, which was able to grow on higher concentr...
ORGANISM(S): Synechococcus sp. WH 8102 
2013-08-01 | E-GEOD-39818 | biostudies-arrayexpress
MetabolomicsMetabolome of pig endometrium and placenta.

Neonatal mortality is mostly due to a reduced piglet maturity. An essential question for adaptation to extra-uterine environment lies in the optimization of the crosstalk between maternal and fetal genomes for a distribution of resources that allows fetuses to express healthier phenotypes at birt...

2025-06-30 | MTBLS3091 | MetaboLights
UnknownInhibition of mast cell-secreted histamine decreases biliary proliferation and fibrosis in primary sclerosing cholangitis Mdr2(-/-) mice.
Not available
S-EPMC5033697 | biostudies-literature
GenomicsWhole-genome analysis of 5-hydroxymethylcytosine and 5-methylcytosine at base resolution in the human brain
5-Hydroxymethylcytosine (hmC) is particularly abundant in mammalian brains with yetto be revealed functions. Here, we present genome-wide and single-base-resolutionmaps of hmC and mC in the human brain. We demonstrated that hmCs increasemarkedly from the fetal to the adult stage, and in the adult br...
ORGANISM(S): Homo sapiens 
2014-02-22 | E-GEOD-55249 | biostudies-arrayexpress
MetabolomicsUntargeted metabolomic profiling of nutrient supplementation during Agaricus bisporus cultivation

This study investigated stage-specific metabolomic responses of Agaricus bisporus compost to a commercial nutrient supplement (MC) compared with an unsupplemented control (CK). Untargeted UHPLC–MS/MS metabolomics was performed across different cultivation stages to characterize metabolite changes...

2026-09-06 | MTBLS15556 | MetaboLights
ProteomicsExtracellular vesicles from pancreatic cancer cells activate mast cells which in turn promote tumor cell proliferation and establish a tumor-supportive microenvironment
Background and aim: Recent studies reveal a critical role of tumor cell-released extracellular vesicles (EVs) in pancreatic cancer progression. Driver genes directing EV function, the EV-recipient cells, as well as their cellular response to EV uptake remain, however, to be identified. To address th...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2023-12-06 | MSV000093583 | MassIVE
GenomicsTet1 and hydroxymethylcytosine in transcription and DNA methylation fidelity (ChIP/DIP-Seq data)
We analyzed the genome-wide binding of Tet1 in control (shScr) and Tet1 knockdown (shTet1) mouse ES cells using two different Tet1 antibodies (Tet1-C and Tet1-N). Furthermore, we generated genome-wide mapping of hydroxymethyl cytosine (hmC) and methyl cytosine (mC). We find that hmC, in contrast to ...
ORGANISM(S): Mus musculus 
2011-04-13 | E-GEOD-24841 | biostudies-arrayexpress
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