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TranscriptomicsFlag Chromatin IP in Cyclin D1 Flag-HA tagged E.14.5 embryos versus Flag Chromatin IP in wildtype E.14.5 embryos
Cyclin D1 belongs to the core cell cycle machinery1, and it is frequently overexpressed in human cancers2. The full repertoire of cyclin D1 functions in normal development and in cancer cells is currently unknown. To address this question, here we introduce a novel approach that allows one to deter...
ORGANISM(S): Mus musculus 
2010-05-15 | E-GEOD-13632 | biostudies-arrayexpress
TranscriptomicsTargets of the transcription factor Brachyury in differentiating mouse ES cells
Brachyury (or T) is expressed in the primitive streak, tailbud and notochord of the early mouse embryo (Herrmann et al., 1990; Wilkinson et al., 1990). It plays a key role in early development: mouse embryos lacking functional Brachyury protein fail to gastrulate properly, do not form a differentiat...
ORGANISM(S): Mus musculus 
2012-05-28 | E-GEOD-16646 | biostudies-arrayexpress
TranscriptomicsA mesodermal gene regulatory network directed by zebrafish No tail
Using chromatin immunoprecipitation combined with microarrays we have identified targets of No tail (Ntl), a zebrafish Brachyury ortholog that plays a central role in mesoderm formation. We show that Ntl regulates a downstream network of other transcription factors and identify an in vivo Ntl bindin...
ORGANISM(S): Danio rerio 
2009-02-19 | E-GEOD-12331 | biostudies-arrayexpress
TranscriptomicsChromatin immunopreciptiation to identify thyroid hormone receptor beta-1 binding sites in mouse cerebellum
chip on chip to identify thyroid hormone receptor responsive gene
ORGANISM(S): Mus musculus 
2009-04-03 | E-MEXP-1801 | biostudies-arrayexpress
TranscriptomicsCharacterisation of LAP/LIP transcriptional signature in human hepatoma cells
BACKGROUND & AIMS: C/EBPbeta is involved in numerous process as carcinogenesis but its role is still not clear due to the existence of an active form (LAP) and an inhibitory form (LIP) of this transcription factor. The main goals of the present research were (i) the identification of genes inversely...
ORGANISM(S): Homo sapiens 
2010-05-22 | E-GEOD-15010 | biostudies-arrayexpress
UnknownUbiquitin-mediated interaction of p210 BCR/ABL with β-catenin supports disease progression in a murine model for chronic myelogenous leukemia.
Not available
S-EPMC3778552 | biostudies-literature
TranscriptomicsAnalyses of cyclin D1 function using a "genetic-proteomic" approach
We examined the transcriptional function of cyclin D1 in mouse development using two approaches. First, we queried association of cyclin D1 with the genome of E14.5 mouse embryos using ChIP-on-chip approach. We observed binding of cyclin D1 to several promoter regions. Second, we compared gene exp...
ORGANISM(S): Mus musculus 
2010-01-28 | E-GEOD-13636 | biostudies-arrayexpress
UnknownModulating proton diffusion and conductivity in metal-organic frameworks by incorporation of accessible free carboxylic acid groups.
Not available
S-EPMC6354967 | biostudies-literature
TranscriptomicsConserved imprinting associated with unique epigenetic signatures in the Arabidopsis genus
In plants, imprinted gene expression occurs in endosperm seed tissue and can be associated with differential DNA methylation between maternal and paternal alleles. Imprinting is theorized to have been selected for because of conflict between parental genomes in offspring, but most studies of imprint...
ORGANISM(S): Arabidopsis lyrata 
2016-09-01 | E-GEOD-76076 | biostudies-arrayexpress
GenomicsDerivation of pre-X inactivation human embryonic stem cells under physiological oxygen concentrations
The presence of two active X chromosomes (XaXa) is a hallmark of the ground state of pluripotency specific to murine embryonic stem cells (ESCs). Human ESCs invariably exhibit signs of X chromosome inactivation (XCI) and are considered developmentally more advanced than their murine counterparts. W...
ORGANISM(S): Homo sapiens 
2010-05-28 | E-GEOD-21141 | biostudies-arrayexpress
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