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TranscriptomicsHSF1 drives a transcriptional program distinct from heat shock to support highly malignant human cancers [gene expression]
Heat-Shock Factor 1 (HSF1), master regulator of the heat-shock response, facilitates malignant transformation, cancer cell survival and proliferation in model systems. The common assumption is that these effects are mediated through regulation of heat-shock protein (HSP) expression. However, the tra...
ORGANISM(S): Homo sapiens 
2012-08-06 | E-GEOD-38232 | biostudies-arrayexpress
GenomicsHSF1 drives a transcriptional program distinct from heat shock to support highly malignant human cancers [ChIP-Seq]
Heat-Shock Factor 1 (HSF1), master regulator of the heat-shock response, facilitates malignant transformation, cancer cell survival and proliferation in model systems. The common assumption is that these effects are mediated through regulation of heat-shock protein (HSP) expression. However, the tra...
ORGANISM(S): Homo sapiens 
2012-08-07 | E-GEOD-38901 | biostudies-arrayexpress
GenomicsTight coordination of protein translation and heat shock factor 1 activation supports the anabolic malignant state [ChIP-Seq]
A unifying characteristic of aggressive cancers is a profound anabolic shift in metabolism to enable sustained proliferation and biomass expansion. The ribosome is centrally situated to sense metabolic states but whether it impacts systems that promote cellular survival is unknown. Here, through ...
ORGANISM(S): Homo sapiens 
2013-07-21 | E-GEOD-45852 | biostudies-arrayexpress
ProteomicsCase_PTMAinducesFilamentation_P124_Lumos
This dataset consists of 8 raw MS files, acquired on Orbitrap FusionLumosTribrid mass spectrometer operated in Data Dependent Acquisition mode. Samples were generated by Nicolas Case and filtration was performed by Brett Larsen. Fractionation and mass spectrometry acquisition was performed by Cassan...
ORGANISM(S): Candida Albicans (ncbitaxon:5476) Mus Musculus (ncbitaxon:10090) 
2021-05-27 | MSV000087531 | MassIVE
TranscriptomicsThe reprogramming of tumor stroma by HSF1 is a potent enabler of malignancy
Stromal cells within the tumor microenvironment are essential for tumor progression and metastasis. Yet surprisingly little is known about the factors that drive the transcriptional reprogramming of stromal cells within tumors. We report that the transcriptional regulator Heat-Shock Factor 1 (HSF1) ...
ORGANISM(S): Mus musculus 
2014-07-31 | E-GEOD-56252 | biostudies-arrayexpress
TranscriptomicsTight coordination of protein translation and heat shock factor 1 activation supports the anabolic malignant state [Gene Expression Data]
A unifying characteristic of aggressive cancers is a profound anabolic shift in metabolism to enable sustained proliferation and biomass expansion. The ribosome is centrally situated to sense metabolic states but whether it impacts systems that promote cellular survival is unknown. Here, through ...
ORGANISM(S): Homo sapiens 
2013-07-21 | E-GEOD-45851 | biostudies-arrayexpress
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