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ProteomicsExtracellular Matrix Signatures of Human Primary Metastatic Colon Cancers and their Liver Metastases
Naba A, Clauser KR, Whittaker CA,Carr SA, Tanabe KK, Hynes RO. 2014
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2014-02-20 | MSV000078555 | MassIVE
TranscriptomicsComparison of Invasive TAM sub-population to General TAM population
The tumor microenvironment modifies the malignancy of tumors. In solid tumors this environment is populated by many macrophages (tumor-associated macrophages; TAMs) that in genetic studies that depleted these cells from mouse models of breast cancer were shown to promote tumor progression to maligna...
ORGANISM(S): Mus musculus 
2010-05-16 | E-GEOD-18295 | biostudies-arrayexpress
TranscriptomicsHighly Aneuploid Zebrafish Malignant Peripheral Nerve Sheath Tumors have Genetic Alterations Similar to Human Cancers
Aneuploidy is a hallmark of human cancers, but most mouse cancer models lack the extensive aneuploidy seen in many human tumors. The zebrafish is becoming an increasingly popular model for studying cancer. Here we report that malignant peripheral nerve sheath tumors (MPNSTs) that arise in zebrafish ...
ORGANISM(S): Danio rerio 
2010-09-08 | E-GEOD-23666 | biostudies-arrayexpress
GenomicsNkx2-1 Represses a Latent Gastric Differentiation Program in Lung Adenocarcinoma
Tissue-specific differentiation programs become dysregulated during cancer evolution. The transcription factor Nkx2-1 is a master regulator of pulmonary differentiation that is downregulated in poorly differentiated lung adenocarcinoma. Here we use conditional murine genetics to study the fate of l...
ORGANISM(S): Mus musculus 
2013-04-09 | E-GEOD-43252 | biostudies-arrayexpress
TranscriptomicsStage-specific sensitivity to p53 restoration in lung cancer
This SuperSeries is composed of the following subset Series: GSE23873: Stage-specific sensitivity to p53 restoration in lung cancer: cell line data GSE23874: Stage-specific sensitivity to p53 restoration in lung cancer: tumor data Refer to individual Series
ORGANISM(S): Mus musculus 
2010-11-24 | E-GEOD-23875 | biostudies-arrayexpress
TranscriptomicsA transcriptional and metabolic signature of primary aneuploidy is present in chromosomally-unstable cancer cells and informs clinical prognosis
In all primary cells analyzed to date, aneuploidy is associated with poor proliferation. Yet, how abnormal karyotypes affect cancer – a disease characterized by both aneuploidy and heightened proliferative capacity – is largely unknown. Here, I demonstrate that the transcriptional alterations caus...
ORGANISM(S): Mus musculus 
2013-10-01 | E-GEOD-49894 | biostudies-arrayexpress
TranscriptomicsMicroRNA expression in Sézary syndrome: Identification, function and diagnostic potential.
MicroRNAs are commonly aberrantly expressed in many cancers. Very little is known of their role in T-cell lymphoma, however. We therefore elucidated the complete miRNome of purified T-cells cells from 21 patients diagnosed with Sézary syndrome (SzS), a rare aggressive primary cutaneous T-cell (CD4+)...
ORGANISM(S): Homo sapiens 
2010-05-12 | E-GEOD-21697 | biostudies-arrayexpress
OtherExtracellular matrix signatures of human primary metastatic colon cancers and their metastases to liver.
Data from MASSIVE, MSV000078555. Experiment: D120204_CoN_2207, file: D120204_MGH_2207_OGE07_rafkt_ft8dt_cc_01.mzml. Published as part of BMC Cancer. 2014 Jul 18;14(1):518 . From the Abstract: {{i}} We have used enrichment of extracellular matrix (ECM) from human patient samples and proteomics to de...
ORGANISM(S): Homo_sapiens_viruses, Human 
GPM32310002460 | GPMDB
Resource Reanalysis 
TranscriptomicsStage-specific sensitivity to p53 restoration in lung cancer: tumor data
Tumorigenesis is a multistep process that results from the sequential accumulation of mutations in key oncogene and tumor-suppressor pathways. The quest to personalize cancer medicine based on targeting these underlying genetic abnormalities presupposes that sustained inactivation of tumor suppresso...
ORGANISM(S): Mus musculus 
2010-11-24 | E-GEOD-23874 | biostudies-arrayexpress
TranscriptomicsDirect Signaling Between Platelets and Cancer Cells Induces an Epithelial-Mesenchymal-Like Transition and Promotes Metastasis
Interactions of cancer cells with the primary tumor microenvironment are important determinants of cancer progression towards metastasis but it is unknown whether additional prometastatic signals are provided during the intravascular transit to the site of metastasis. Here, we show that transient pl...
ORGANISM(S): Mus musculus 
2011-12-13 | E-GEOD-27456 | biostudies-arrayexpress
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