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GenomicsGenome-wide profiling of Zfp335 binding sites in thymocytes
The generation of naM-CM-/ve T lymphocytes is critical for immune function yet the mechanisms governing their maturation remain incompletely understood. We have identified a mouse mutant, bloto, that harbors a hypomorphic mutation in the zinc finger protein Zfp335. Mutant blt/blt mice exhibit a naM-...
ORGANISM(S): Mus musculus 
2014-10-17 | E-GEOD-58333 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse CD4 cells isolated from an ENU induced mutant Sanroque vs. wildtype
Male C57BL/6 mice were treated with ENU to generate single base substitutions, the variant genome sequences were breed to homozygosity in inbreeding pedigrees, and screened for antinuclear autoantibodies (ANA). The sanroque pedigree contained multiple progeny with ANA of mixed homogeneous nuclear a...
ORGANISM(S): Mus musculus 
2008-06-12 | E-GEOD-2376 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of recent thymic emigrants (RTEs) from a mouse strain with an ENU-induced mutation in Zfp335
The generation of naM-CM-/ve T lymphocytes is critical for immune function yet the mechanisms governing their maturation remain incompletely understood. We have identified a mouse mutant, bloto, that harbors a hypomorphic mutation in the zinc finger protein Zfp335. Mutant blt/blt mice exhibit a naM-...
ORGANISM(S): Mus musculus 
2014-10-17 | E-GEOD-58289 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of mature CD4 SP thymocytes from a mouse strain with an ENU-induced mutation in Zfp335
The generation of naM-CM-/ve T lymphocytes is critical for immune function yet the mechanisms governing their maturation remain incompletely understood. We have identified a mouse mutant, bloto, that harbors a hypomorphic mutation in the zinc finger protein Zfp335. Mutant blt/blt mice exhibit a naM-...
ORGANISM(S): Mus musculus 
2014-10-17 | E-GEOD-58288 | biostudies-arrayexpress
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