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ProteomicsOligodendroglial fatty acid metabolism as a central nervous system energy reserve
Brain function requires a constant supply of glucose. However, the brain has no known energy stores, except for glycogen granules in astrocytes. Here, we addressed the question whether oligodendroglial lipid metabolism can provide an energy reserve in white matter tracts. Among other approaches incl...
ORGANISM(S): Mus musculus (Mouse) 
2024-07-16 | PXD053960 | Pride
Label-free protein quantification Lipid metabolism Mass spectrometry Myelin Whole optic nerve proteome Optic nerve Oligodendrocytes 
ProteomicsWhite matter integrity requires continuous myelin synthesis at the inner tongue
Myelin, the electrically insulating axonal sheath, is composed of lipids and proteins with exceptionally long lifetime. Using 3D electron microscopy, mass spectrometry imaging, and quantitative proteome analysis, we addressed the question how myelin function is affected by myelin turnover. We studie...
ORGANISM(S): Mus musculus (Mouse) 
2022-01-14 | PXD025180 | Pride
Shiverer Myelin basic protein (mbp) Myelinoid body Juxtaparanode Myelin turnover Whole optic nerve proteome Optic nerve Fib-sem 3d reconstruction Nanosims 
TranscriptomicsEffects of dietary curcumin on the colon proteome and transcriptome in the Mdr1a-/- mouse model of inflammatory bowel disease
This study assessed gene expression changes associated with inflammation in the colon tissue of multi-drug resistance targeted mutation (Mdr1a-/-) mice, a model of human IBD. It also tested the anti-inflammatory potential of curcumin in the colon of these mice with a particular focus on the proteome...
ORGANISM(S): Mus musculus 
2014-10-02 | E-GEOD-61939 | biostudies-arrayexpress
TranscriptomicsModulation of colonic inflammation in Mdr1a-/- mice by green tea polyphenols and their effects on the colon transcriptome and proteome
This study tested the anti-inflammatory potential of a green tea extract rich in polyphenols (GrTP) in the colon of the multi-drug resistance targeted mutation (Mdr1a-/-) mouse model of IBD. A colonic histological injury score was determined for each mouse to establish the effect of GrTP on inflamma...
ORGANISM(S): Mus musculus 
2012-10-18 | E-GEOD-41644 | biostudies-arrayexpress
TranscriptomicsExpression data from colon and livers of mice
Here we describe our unprecedented approach in proposing parsley (PAR) as a nutraceutical intervention in inflammatory bowel disease (IBD) using a mouse model of dextran sodium sulphate (DSS)-induced colitis, following a multi-integrated-omics analysis. PAR supplementation (n=7) significantly improv...
ORGANISM(S): Mus musculus 
2014-01-24 | E-GEOD-54349 | biostudies-arrayexpress
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