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MetabolomicsMetabolically-incorporated deuterium in myelin localized by neutron diffraction and identified by mass spectrometry
Myelin is a natural and dynamic multilamellar membrane structure that continues to be of significant biological and neurological interest, especially with respect to its biosynthesis and assembly during its normal formation and maintenance, and pathological breakdown. To explore the usefulness of ne...
2024-09-27 | MTBLS4717 | MetaboLights
TranscriptomicsThe transcriptome of central nervous system myelin
Rapid nerve conduction in the CNS is facilitated by the insulation of axons with myelin, a specialized oligodendroglial compartment distant from the cell body. Myelin is turned over and adapted throughout life; however, the molecular and cellular basis of myelin dynamics is not well understood. Hypo...
ORGANISM(S): Mus musculus 
2016-06-24 | E-GEOD-78151 | biostudies-arrayexpress
TranscriptomicsRetinoid X Receptor activation reverses the age-related deficiency in myelin debris phagocytosis and enhances remyelination
The efficiency of central nervous system (CNS) remyelination declines with age. This is in part due to an age-associated decline in the phagocytic removal of myelin debris, which contains inhibitors of oligodendrocyte progenitor cell differentiation. In this study we show that expression of genes i...
ORGANISM(S): Homo sapiens 
2015-11-04 | E-GEOD-66988 | biostudies-arrayexpress
ProteomicsMyelin proteome differences in old and young mice
Aging of the peripheral nervous system (PNS) is associated with structural and functional changes that lead to a reduction in regenerative capacity and the development of age-related peripheral neuropathy. Myelin is a central component in maintaining physiological peripheral nerve function, and dif...
ORGANISM(S): Mus musculus (Mouse) 
2023-10-19 | PXD040719 | Pride
Myelin Peripheral nervous system Neuropathy 
ProteomicsMyelin proteome alterations upon oligodendroglial deletion of CDC42 and its effector proteins CDC42EP1/CDC42EP2
The regular structure of healthy CNS myelin sheaths requires specialized structural proteins, including septin filaments composed of subunits SEPTIN2, SEPTIN4, SEPTIN7, and SEPTIN8. Their assembly scaffolds the innermost non-compacted myelin layer as a late step of CNS myelin maturation and their di...
ORGANISM(S): Mus musculus (Mouse) 
2025-12-30 | PXD066943 | Pride
Label-free protein quantification White matter Cytoskeleton Oligodendrocyte Septins Mass spectrometry Myelination Myelin pathology Myelin proteome 
TranscriptomicsIdentification of Myelin-gene Regulatory Factor as a Critical Transcriptional Regulator Required for CNS Myelination
The transcriptional control of CNS myelin gene expression is poorly understood. Here we identify gene model 98, which we have named Myelin-gene Regulatory Factor (MRF), as a transcriptional regulator required for CNS myelination. Within the CNS, MRF is specifically expressed by postmitotic oligodend...
ORGANISM(S): Mus musculus 
2009-05-31 | E-GEOD-15303 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of myelin-phagocytosing macrophages
Multiple sclerosis is a chronic, inflammatory, demyelinating disease of the central nervous system in which macrophages and microglia play a central role. During active multiple sclerosis foamy macrophages and microglia, containing degenerated myelin, are abundantly found in demyelinated areas. Rece...
ORGANISM(S): Rattus norvegicus 
2012-08-20 | E-GEOD-34811 | biostudies-arrayexpress
ProteomicsProteome profile of myelin in the zebrafish brain
While the myelin proteome is well characterized in mice, much less is known about the protein composition of myelin in non-mammalian species such as zebrafish (Danio rerio), despite its increasing popularity as model organism for myelin biology. Here, we assess the proteome of myelin biochemically p...
ORGANISM(S): Danio rerio (Zebrafish) (Brachydanio rerio) 
2021-03-22 | PXD023037 | Pride
Transcriptome Oligodendrocyte Mbp Label-free proteomics Teleost Cd59 Central nervous system (cns) Mpz Danio rerio Plp Zebrafish Myelin proteome 
ProteomicsThe CNS myelin proteome: Deep profile and persistence after post-mortem delay
We revisited the proteome of myelin biochemically purified from the brains of healthy c56Bl/6N-mice utilizing complementary proteomic approaches for deep qualitative and quantitative coverage. A data-independent acquisition (DIA) workflow with alternating low and elevated energy (MSE) provided the h...
ORGANISM(S): Mus musculus (Mouse) 
2020-07-16 | PXD020007 | Pride
Mass spectrometry Oligodendrocyte Proteolipid protein (plp) Central nervous system (cns) Label-free proteomics Myelin basic protein (mbp) Post mortem-delay Cyclic nucleotide phosphodiesterase (cnp) Myelin proteome Transcriptome Demyelination Autopsy 
ProteomicsProteomics analysis of myelin from GLTP KO mouse brains
To better understand the effects of GLTP cKO at the molecular level, we performed proteomics analysis of myelin purified from P28 Gltp cKO and Cre control mice.
ORGANISM(S): Mus musculus (Mouse) 
2024-09-18 | PXD055984 | Pride
Gltp Myelin Oligodendrocytes 
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