Sort   by:  
 Page size 
MetabolomicsIntegration of whole-body [18F]FDG PET/MRI with non-targeted metabolomics can provide new insights on tissue-specific insulin resistance in type 2 diabetes
Alteration of various metabolites has been linked to type 2 diabetes (T2D) and insulin resistance. However, identifying significant associations between metabolites and tissue-specific phenotypes requires a multi-omics approach. In a cohort of 42 subjects with different levels of glucose tolerance (...
2020-01-06 | MTBLS1051 | MetaboLights
TranscriptomicsImpact of whole-body versus nose-only exposure systems on systemic, respiratory, and cardiovascular endpoints in a 2-month cigarette smoke exposure study in the ApoE-/- mouse model
In vivo inhalation toxicity is typically tested in rodents by using either whole-body (WB) or nose-only (NO) exposure systems. To assess if cigarette smoke (CS)-induced disease endpoints would be similar after exposure in either system, we exposed apolipoprotein E-deficient mice to the same target t...
ORGANISM(S): Mus musculus 
2021-03-16 | E-MTAB-9248 | biostudies-arrayexpress
ClinicalDiffusion-weighted whole-body imaging with background body signal suppression (DWIBS) for colorectal cancer screening.
Interventions: 1. Diffusion-weighted whole-body imaging with background body signal suppression (DWIBS); 2. Colonoscopy. Primary outcome(s): Investigate whether DWIBS is effective for colorectal cancer screening. Study Design: N/A: single arm study, Single blinded (masking used), N/A , unknown, Cros...
15948 | ecrin-mdr-crc
TranscriptomicsHigh content imaging in the screening of biomaterial-induced MSC behavior
Upon contact with a biomaterial, cells and surrounding tissues respond in a manner dictated by the physicochemical and mechanical properties of the material. Traditionally, cellular responses are monitored using invasive analytical methods that report the expression of genes or proteins. These analy...
ORGANISM(S): Homo sapiens 
2018-11-10 | E-MTAB-7352 | biostudies-arrayexpress
MetabolomicsConnecting structure and function from organisms to molecules in small-animal symbioses through chemo-histo-tomography
Our understanding of metabolic interactions between small symbiotic animals and bacteria or parasitic eukaryotes that reside within their bodies is extremely limited. This gap in knowledge originates from a methodological challenge, namely to connect histological changes in host tissues induced by b...
2021-07-06 | MTBLS2639 | MetaboLights
ProteomicsNanocarrier imaging at single-cell resolution across entire mouse bodies with deep learning
Efficient and accurate nanocarrier development for targeted drug delivery is hindered by the inability to analyze cell-level biodistribution across intact whole organisms. We introduce SCP-Nano (Single Cell Precision Nanocarrier Identification), a deep learning pipeline designed to quantify the targ...
ORGANISM(S): Mus musculus (Mouse) 
2024-12-06 | PXD056871 | Pride
Tissue clearing Single-cell resolution Whole-body imaging Ai Nanocarriers 
ProteomicsA deep-learning framework reveals whole-body perturbations at cell level
Many diseases, including obesity, have systemic effects that perturb multiple organ systems throughout the body. However, tools for comprehensive, high-resolution analysis of disease-associated changes at the whole-body scale have been lacking. Here we developed MouseMapper, a suite of foundation-mo...
ORGANISM(S): Homo sapiens (Human) 
2026-05-06 | PXD071172 | Pride
Human Brain Bruker Mouse Timstofscp Obesity Ganglion 
UnknownExperimental validation of a PNS-optimized whole-body gradient coil.
Not available
S-EPMC11262990 | biostudies-literature
UnknownTowards whole-body fluorescence imaging in humans.
Not available
S-EPMC3877082 | biostudies-literature
TranscriptomicsEpigenetic environment of histone H3.3 on promoters revealed by integration of imaging, ChIP-chip, and MeDIP-chip data
Epigenetic environment of histone H3.3 on promoters revealed by integration of imaging and genome-scale chromatin and methyl-DNA immunoprecipitation information. Chromatin regions with different transcriptional outputs are distinguished by the deposition of histone variants. Histone H3.3 is incorpor...
ORGANISM(S): Homo sapiens 
2010-05-12 | E-GEOD-17053 | biostudies-arrayexpress
Sort   by:  
 Page size