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MetabolomicsShotgun lipidomics of HeLa whole-cell lysates and lysosomes following LLOMe treatment

Perturbations in lysosome integrity are tightly linked to neurological disorders and ageing, but the underlying pathogenic mechanisms are incompletely understood. Using an unbiased proteomic approach, we here identified the bridge-like lipid transport protein VPS13C/PARK23 as a key component of a...

2026-07-03 | MTBLS14737 | MetaboLights
MetabolomicsCell Membrane Remodeling Mediates Polymyxin B Resistance in Klebsiella pneumoniae: An Integrated Proteomics and Metabolomics Study
Polymyxin B (PB) is introduced into the clinic as the last-line therapy against carbapenem-resistant Klebsiella pneumoniae (CRKP). Unfortunately, increased resistance to PB in Klebsiella pneumoniae (K. pneumoniae) has threatened global health. Resistance of K. pneumoniae ...
2022-03-04 | MTBLS4132 | MetaboLights
MetabolomicsBiological Characteristics of SARS-CoV-2 Resistant Populations: A Cohort Comparison Study through Integrated Gut Microbiota Sequencing, Metabolomics and Proteomics

Objective: Most research reports on COVID-19 infections have focused on the correlation between the severity of the disease symptoms and immune deficits, while the mechanisms affecting the susceptibility to SARS-CoV-2 remain largely unknown. The study aimed to comprehensively analyze the differen...

2025-06-28 | MTBLS12654 | MetaboLights
ProteomicsMus musculus primary CD4+ T cell di-glycine remnant and whole cell proteomics
It is known that ubiquitination is important for T cell receptor (TCR) signaling during T cell activation but the breadth of ubiquitination events triggered during TCR signaling is not completely understood. This dataset utilizes di-glycine remnant profiling combined with mass spectrometry to identi...
ORGANISM(S): Mus musculus (Mouse) 
2019-05-09 | PXD012831 | Pride
Mus musculus primary cd4+ t cell di-glycine remnant and whole cell proteomics 
ProteomicsOocyte-Inspired Universal Whole-Cell Vaccines Against Tumor Heterogeneity
Inspired by the zona pellucida, an extracellular armor that safeguards the oocyte, we engineered a biomimetic whole-tumor-cell vaccine whose mechanical properties can be precisely tuned while preserving the full spectrum of native tumor antigens.
ORGANISM(S): Mus Musculus 
2026-03-20 | PXD075990 |
ProteomicsWhole cell proteome of cells lacking heme biosynthesis enzyme CPOX
Whole cell proteomics of a CRISPR/Cas9-generated HEK293 FLP/IN/T-Rex CPOX KO cell line in comparison to HEK293 FLP/IN/T-Rex WT cells and HEK293 FLP/IN/T-Rex CPOX KO cells complemented with CPOX-HA WT.
ORGANISM(S): Homo sapiens (Human) 
2026-04-16 | PXD064668 | Pride
Mitochondria  cpox  ims  heme biosynthesis 
TranscriptomicsTranscription profiling of neutrophils isolated by microfluidics: Clinical Microfluidics for Neutrophil Genomics and Proteomics
Neutrophils play critical roles in modulating the immune response. However, neutrophils have a short circulating half life, are readily stimulated in vitro, and have low levels of cellular mRNA when compared to other blood leukocyte populations. All of these factors have made it difficult to evaluat...
ORGANISM(S): Homo sapiens 
2010-06-16 | E-GEOD-22103 | biostudies-arrayexpress
ProteomicsAeromonas hydrophila whole cell differential proteins
Differential protein of Aeromonas hydrophila(putative human infections)'s whole cell protein
ORGANISM(S): Aeromonas sp. enrichment culture clone AM2 Escherichia coli 
2022-01-13 | PXD029702 | Pride
Differential protein  aeromonas hydrophila  whole cell protein  putative human infections  logarithmic period cell 
ProteomicsThe Whole cell lysate and Crude membrane of HEK293T cells
We perform the experiment in order to compare identified membrane proteins from whole cell lysate and membrane fraction in HEK293T cell. The isolation of membrane fractions is critical to obtain a more comprehensive membrane proteome, especially with proteins containing transmembrane domains.
ORGANISM(S): Homo Sapiens (human) 
2022-04-28 | PXD027472 | JPOST Repository
ProteomicsWhole cell proteomics of NDUFAF8 knock-out cell line and NDUFAF5 knock-out cell line
Comparison of whole cell proteome of NDUFAF8 KO and NDUFAF5 KO to WT cell line
ORGANISM(S): Homo sapiens (Human) 
2023-05-08 | PXD040441 | Pride
Ndufaf5 Ndufaf8 
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