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TranscriptomicsA compendium of hematopoietic regulators, chromatin modifiers and basal transcription factors occupy CBF-MYH11/RUNX1 target genes
Different mechanisms for CBF-MYH11 function in acute myeloid Leukemia (AML) with inv(16) have been proposed such as tethering of RUNX1 outside the nucleus, interference with transcription factor complex assembly and recruitment of histone deacetylases, all resulting in transcriptional repression of ...
ORGANISM(S): Homo sapiens 
2013-09-09 | E-GEOD-46044 | biostudies-arrayexpress
UnknownOcrelizumab associates with reduced cerebrospinal fluid B and CD20dim CD4+ T cells in primary progressive multiple sclerosis.
Not available
S-EPMC10881107 | biostudies-literature
TranscriptomicsIdentification of STAT5 target genes in human CB HSC, CMP, GMP and MEP
CB CD34+ cells were isolated by Miltenyi miniMACS column. Cells were prestimulated in HPGM with 100 ng/ml KITL, FLT#L and TPO for 48 hrs. Cells were transduced with control MiNR1 or STAT5A-ER in three rounds over 48 hrs. Hematopoietic stem cells (HSCs), common myeloid progenitors (CMPs), granulocyte...
ORGANISM(S): Homo sapiens 
2011-01-22 | E-GEOD-26775 | biostudies-arrayexpress
UnknownChanges in N:P Supply Ratios Affect the Ecological Stoichiometry of a Toxic Cyanobacterium and Its Fungal Parasite.
Not available
S-EPMC5459933 | biostudies-literature
ProteomicsThe FIGNL1-interacting protein C1orf112 is synthetic lethal with PICH and mediates RAD51 retention on chromatin
Joint DNA molecules are natural by-products of DNA replication and repair. Persistent joint molecules give rise to ultrafine DNA bridges (UFBs) in mitosis, which compromise sister chromatid separation. The DNA translocase PICH (ERCC6L) plays a central role in UFB resolution. To better understand the...
ORGANISM(S): Homo sapiens (Human) 
2024-08-08 | PXD035876 | Pride
Homologous recombination rad51 c1orf112 dna repair flag ip 
UnknownSelective emergence of antibody-secreting cells in the multiple sclerosis brain.
Not available
S-EPMC9958261 | biostudies-literature
UnknownSemaphorin4D Induces Inhibitory Synapse Formation by Rapid Stabilization of Presynaptic Boutons via MET Coactivation.
Not available
S-EPMC6538862 | biostudies-literature
ProteomicsLabel-free quantitative proteome of CD34+ or CKIT+ AML cells and mobilized PB CD34+ cells
The label-free quantitative proteome was generated for 30 primary AML patient samples enriched for CD34+ cells or CKIT+ cells in the case of NPMcyt samples. As controls 3 mobilized peripheral blood CD34+ cells were included.
ORGANISM(S): Homo sapiens (Human) 
2025-01-07 | PXD030487 | Pride
Acute myeloid leukemia Leukemic stem/progenitor cells 
UnknownInteroception and Mental Health: A Roadmap.
Not available
S-EPMC6054486 | biostudies-literature
UnknownGermline De Novo Mutations in GNB1 Cause Severe Neurodevelopmental Disability, Hypotonia, and Seizures.
Not available
S-EPMC4863562 | biostudies-literature
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